TY - JOUR
T1 - Correlation between angiogenesis and reduction ratio measured using 201T1 chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma
AU - Suzuki, Aya
AU - Togawa, Takashi
AU - Kuyama, Junpei
AU - Nakahara, Tadaki
AU - Takenouchi, Toshinao
AU - Hatano, Kazuo
AU - Omura, Ken
PY - 2004/10
Y1 - 2004/10
N2 - Objective: The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201T1 single photon emission computed tomography (T1 SPECT) in oral cavity squamous cell carcinoma (SCC). Methods: T1 SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating micro vessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using T1 SPECT (T/N at pre- an post-treatment, reduction ratio) and prognosis. Results: The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence. Conclusions: In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of 201T1 uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.
AB - Objective: The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201T1 single photon emission computed tomography (T1 SPECT) in oral cavity squamous cell carcinoma (SCC). Methods: T1 SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating micro vessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using T1 SPECT (T/N at pre- an post-treatment, reduction ratio) and prognosis. Results: The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence. Conclusions: In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of 201T1 uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.
KW - CD31
KW - Microvessel density
KW - Oral cavity squamous cell carcinoma
KW - Preoperative radiotherapy
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U2 - 10.1007/BF02984582
DO - 10.1007/BF02984582
M3 - Article
C2 - 15586634
AN - SCOPUS:10044271820
VL - 18
SP - 599
EP - 607
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
SN - 0914-7187
IS - 7
ER -