Correlation between angiogenesis and reduction ratio measured using 201T1 chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma

Aya Suzuki, Takashi Togawa, Junpei Kuyama, Tadaki Nakahara, Toshinao Takenouchi, Kazuo Hatano, Ken Omura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201T1 single photon emission computed tomography (T1 SPECT) in oral cavity squamous cell carcinoma (SCC). Methods: T1 SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating micro vessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using T1 SPECT (T/N at pre- an post-treatment, reduction ratio) and prognosis. Results: The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence. Conclusions: In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of 201T1 uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.

Original languageEnglish
Pages (from-to)599-607
Number of pages9
JournalAnnals of Nuclear Medicine
Volume18
Issue number7
Publication statusPublished - 2004 Oct
Externally publishedYes

Fingerprint

Microvessels
Single-Photon Emission-Computed Tomography
Mouth
Chlorides
Squamous Cell Carcinoma
Radiotherapy
Scalp
Neoplasms
Monoclonal Antibodies
Staining and Labeling
Biopsy
Recurrence
Therapeutics

Keywords

  • T1 chloride single photon emission tomography
  • CD31
  • Microvessel density
  • Oral cavity squamous cell carcinoma
  • Preoperative radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Correlation between angiogenesis and reduction ratio measured using 201T1 chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma. / Suzuki, Aya; Togawa, Takashi; Kuyama, Junpei; Nakahara, Tadaki; Takenouchi, Toshinao; Hatano, Kazuo; Omura, Ken.

In: Annals of Nuclear Medicine, Vol. 18, No. 7, 10.2004, p. 599-607.

Research output: Contribution to journalArticle

@article{e49d8ba78b014faf8a2930171635a19e,
title = "Correlation between angiogenesis and reduction ratio measured using 201T1 chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma",
abstract = "Objective: The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201T1 single photon emission computed tomography (T1 SPECT) in oral cavity squamous cell carcinoma (SCC). Methods: T1 SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating micro vessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using T1 SPECT (T/N at pre- an post-treatment, reduction ratio) and prognosis. Results: The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence. Conclusions: In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of 201T1 uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.",
keywords = "T1 chloride single photon emission tomography, CD31, Microvessel density, Oral cavity squamous cell carcinoma, Preoperative radiotherapy",
author = "Aya Suzuki and Takashi Togawa and Junpei Kuyama and Tadaki Nakahara and Toshinao Takenouchi and Kazuo Hatano and Ken Omura",
year = "2004",
month = "10",
language = "English",
volume = "18",
pages = "599--607",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",
number = "7",

}

TY - JOUR

T1 - Correlation between angiogenesis and reduction ratio measured using 201T1 chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma

AU - Suzuki, Aya

AU - Togawa, Takashi

AU - Kuyama, Junpei

AU - Nakahara, Tadaki

AU - Takenouchi, Toshinao

AU - Hatano, Kazuo

AU - Omura, Ken

PY - 2004/10

Y1 - 2004/10

N2 - Objective: The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201T1 single photon emission computed tomography (T1 SPECT) in oral cavity squamous cell carcinoma (SCC). Methods: T1 SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating micro vessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using T1 SPECT (T/N at pre- an post-treatment, reduction ratio) and prognosis. Results: The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence. Conclusions: In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of 201T1 uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.

AB - Objective: The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201T1 single photon emission computed tomography (T1 SPECT) in oral cavity squamous cell carcinoma (SCC). Methods: T1 SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating micro vessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using T1 SPECT (T/N at pre- an post-treatment, reduction ratio) and prognosis. Results: The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence. Conclusions: In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of 201T1 uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.

KW - T1 chloride single photon emission tomography

KW - CD31

KW - Microvessel density

KW - Oral cavity squamous cell carcinoma

KW - Preoperative radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=10044271820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10044271820&partnerID=8YFLogxK

M3 - Article

C2 - 15586634

AN - SCOPUS:10044271820

VL - 18

SP - 599

EP - 607

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 7

ER -