Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Yusuke Tanigawara; Kiyoshi Yamaoka; Terumichi Nakagawa; Mutsumi Nakagawa; Toyozo Uno

doi:10.1248/bpb1978.5.370

Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Mutsumi Nakagawa, Toyozo Uno

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

Original language	English
Pages (from-to)	370-372
Number of pages	3
Journal	Journal of Pharmacobio-Dynamics
Volume	5
Issue number	5
DOIs	https://doi.org/10.1248/bpb1978.5.370
Publication status	Published - 1982
Externally published	Yes

Keywords

ampicillin
bioavailability
bioequivalence
in vivo-in vitro correlation
mean dissolution time
moments

ASJC Scopus subject areas

Pharmacology

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10.1248/bpb1978.5.370

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title = "Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products",

abstract = "The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).",

keywords = "ampicillin, bioavailability, bioequivalence, in vivo-in vitro correlation, mean dissolution time, moments",

author = "Yusuke Tanigawara and Kiyoshi Yamaoka and Terumichi Nakagawa and Mutsumi Nakagawa and Toyozo Uno",

year = "1982",

doi = "10.1248/bpb1978.5.370",

language = "English",

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pages = "370--372",

journal = "Biological and Pharmaceutical Bulletin",

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T1 - Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

AU - Tanigawara, Yusuke

AU - Yamaoka, Kiyoshi

AU - Nakagawa, Terumichi

AU - Nakagawa, Mutsumi

AU - Uno, Toyozo

PY - 1982

Y1 - 1982

N2 - The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

AB - The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

KW - ampicillin

KW - bioavailability

KW - bioequivalence

KW - in vivo-in vitro correlation

KW - mean dissolution time

KW - moments

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SN - 0918-6158

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EP - 372

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

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ER -

Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Abstract

Keywords

ASJC Scopus subject areas

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