Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Mutsumi Nakagawa, Toyozo Uno

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The mean in vitro dissolution times {in vitro MDT) of ampicillin products were evaluated from the dissolution curves in distilled water using the USP-XX dissolution apparatus, and were compared with the mean in vivo dissolution times (in vivo MDT) reported previously. In both in vivo and in vitro cases, MDT of the trihydrate capsule was greater than those of the anhydrate capsules. A good linear correlation was observed between in vivo and in vitro MDT (r = 0.999, p <0.001).

Original languageEnglish
Pages (from-to)370-372
Number of pages3
JournalJournal of Pharmacobio-Dynamics
Volume5
Issue number5
DOIs
Publication statusPublished - 1982 Jan 1
Externally publishedYes

Keywords

  • ampicillin
  • bioavailability
  • bioequivalence
  • in vivo-in vitro correlation
  • mean dissolution time
  • moments

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products'. Together they form a unique fingerprint.

  • Cite this