Correlation between insulin resistance and γ-glutamyl transpeptidase sensitivity in light drinkers

Susumu Moriya, Hirokazu Yokoyama, Hiroshi Hirose, Hiromasa Ishii, Ikuo Saito

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Our previous studies suggested that serum γ-glutamyl transpeptidase (GGTP) level was correlated with insulin resistance level estimated by the homeostasis model assessment in teetotalers and occasional drinkers. In the surveys, strong correlation between GGTP and triglyceride also was observed. This study examined whether the correlation held true for regular drinkers. Methods: Seven hundred and seventeen male subjects in annual health checkups were divided into three groups according to their drinking styles and further divided into four subgroups according to their serum GGTP levels. In the other surveys, they were ranked by their amount of ethanol consumption. The correlation between GGTP and insulin resistance level was studied in each group. Results: Single regression analysis and analysis of variance showed that GGTP level was significantly correlated with insulin resistance level as determined by the homeostasis model assessment, as well as with triglyceride level regardless of subjects' drinking styles. The associations were confirmed by multiple regression analyses in which age, levels of uric acid, total cholesterol, high-density lipoprotein cholesterol, and body mass index were adjusted, at least in nondrinkers or light drinkers. However, the multiple regression analyses indicated that the association between GGTP and insulin resistance level was not significant in subjects who take ethanol more than five times per week. The studies according to the amount of subjects' ethanol consumption indicated that the association between GGTP and insulin resistance was significant in the subjects who take ethanol up to 280 g/week. Conclusion: Individual variation in insulin resistance status may contribute to individual variations of sensitivity of GGTP to ethanol intake, at least in light drinkers.

Original languageEnglish
JournalAlcoholism: Clinical and Experimental Research
Volume27
Issue number8 SUPPL.
Publication statusPublished - 2003 Aug 1

Fingerprint

Photophobia
gamma-Glutamyltransferase
Insulin Resistance
Insulin
Ethanol
Regression Analysis
Drinking
Triglycerides
Homeostasis
Cholesterol
Analysis of variance (ANOVA)
Uric Acid
Serum
Regression analysis
HDL Cholesterol
Analysis of Variance
Body Mass Index
Health

Keywords

  • γ-Glutamyl Transpeptidase
  • Insulin Resistance
  • Triglycerides

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Correlation between insulin resistance and γ-glutamyl transpeptidase sensitivity in light drinkers. / Moriya, Susumu; Yokoyama, Hirokazu; Hirose, Hiroshi; Ishii, Hiromasa; Saito, Ikuo.

In: Alcoholism: Clinical and Experimental Research, Vol. 27, No. 8 SUPPL., 01.08.2003.

Research output: Contribution to journalArticle

@article{5c86bd4fdfcf4447a67bdb27c241aa3c,
title = "Correlation between insulin resistance and γ-glutamyl transpeptidase sensitivity in light drinkers",
abstract = "Background: Our previous studies suggested that serum γ-glutamyl transpeptidase (GGTP) level was correlated with insulin resistance level estimated by the homeostasis model assessment in teetotalers and occasional drinkers. In the surveys, strong correlation between GGTP and triglyceride also was observed. This study examined whether the correlation held true for regular drinkers. Methods: Seven hundred and seventeen male subjects in annual health checkups were divided into three groups according to their drinking styles and further divided into four subgroups according to their serum GGTP levels. In the other surveys, they were ranked by their amount of ethanol consumption. The correlation between GGTP and insulin resistance level was studied in each group. Results: Single regression analysis and analysis of variance showed that GGTP level was significantly correlated with insulin resistance level as determined by the homeostasis model assessment, as well as with triglyceride level regardless of subjects' drinking styles. The associations were confirmed by multiple regression analyses in which age, levels of uric acid, total cholesterol, high-density lipoprotein cholesterol, and body mass index were adjusted, at least in nondrinkers or light drinkers. However, the multiple regression analyses indicated that the association between GGTP and insulin resistance level was not significant in subjects who take ethanol more than five times per week. The studies according to the amount of subjects' ethanol consumption indicated that the association between GGTP and insulin resistance was significant in the subjects who take ethanol up to 280 g/week. Conclusion: Individual variation in insulin resistance status may contribute to individual variations of sensitivity of GGTP to ethanol intake, at least in light drinkers.",
keywords = "γ-Glutamyl Transpeptidase, Insulin Resistance, Triglycerides",
author = "Susumu Moriya and Hirokazu Yokoyama and Hiroshi Hirose and Hiromasa Ishii and Ikuo Saito",
year = "2003",
month = "8",
day = "1",
language = "English",
volume = "27",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "8 SUPPL.",

}

TY - JOUR

T1 - Correlation between insulin resistance and γ-glutamyl transpeptidase sensitivity in light drinkers

AU - Moriya, Susumu

AU - Yokoyama, Hirokazu

AU - Hirose, Hiroshi

AU - Ishii, Hiromasa

AU - Saito, Ikuo

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Background: Our previous studies suggested that serum γ-glutamyl transpeptidase (GGTP) level was correlated with insulin resistance level estimated by the homeostasis model assessment in teetotalers and occasional drinkers. In the surveys, strong correlation between GGTP and triglyceride also was observed. This study examined whether the correlation held true for regular drinkers. Methods: Seven hundred and seventeen male subjects in annual health checkups were divided into three groups according to their drinking styles and further divided into four subgroups according to their serum GGTP levels. In the other surveys, they were ranked by their amount of ethanol consumption. The correlation between GGTP and insulin resistance level was studied in each group. Results: Single regression analysis and analysis of variance showed that GGTP level was significantly correlated with insulin resistance level as determined by the homeostasis model assessment, as well as with triglyceride level regardless of subjects' drinking styles. The associations were confirmed by multiple regression analyses in which age, levels of uric acid, total cholesterol, high-density lipoprotein cholesterol, and body mass index were adjusted, at least in nondrinkers or light drinkers. However, the multiple regression analyses indicated that the association between GGTP and insulin resistance level was not significant in subjects who take ethanol more than five times per week. The studies according to the amount of subjects' ethanol consumption indicated that the association between GGTP and insulin resistance was significant in the subjects who take ethanol up to 280 g/week. Conclusion: Individual variation in insulin resistance status may contribute to individual variations of sensitivity of GGTP to ethanol intake, at least in light drinkers.

AB - Background: Our previous studies suggested that serum γ-glutamyl transpeptidase (GGTP) level was correlated with insulin resistance level estimated by the homeostasis model assessment in teetotalers and occasional drinkers. In the surveys, strong correlation between GGTP and triglyceride also was observed. This study examined whether the correlation held true for regular drinkers. Methods: Seven hundred and seventeen male subjects in annual health checkups were divided into three groups according to their drinking styles and further divided into four subgroups according to their serum GGTP levels. In the other surveys, they were ranked by their amount of ethanol consumption. The correlation between GGTP and insulin resistance level was studied in each group. Results: Single regression analysis and analysis of variance showed that GGTP level was significantly correlated with insulin resistance level as determined by the homeostasis model assessment, as well as with triglyceride level regardless of subjects' drinking styles. The associations were confirmed by multiple regression analyses in which age, levels of uric acid, total cholesterol, high-density lipoprotein cholesterol, and body mass index were adjusted, at least in nondrinkers or light drinkers. However, the multiple regression analyses indicated that the association between GGTP and insulin resistance level was not significant in subjects who take ethanol more than five times per week. The studies according to the amount of subjects' ethanol consumption indicated that the association between GGTP and insulin resistance was significant in the subjects who take ethanol up to 280 g/week. Conclusion: Individual variation in insulin resistance status may contribute to individual variations of sensitivity of GGTP to ethanol intake, at least in light drinkers.

KW - γ-Glutamyl Transpeptidase

KW - Insulin Resistance

KW - Triglycerides

UR - http://www.scopus.com/inward/record.url?scp=0042163142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042163142&partnerID=8YFLogxK

M3 - Article

C2 - 12960508

AN - SCOPUS:0042163142

VL - 27

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 8 SUPPL.

ER -