Correlation between laminin-5 γ2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue

Kazuhide Katoh, Yukihiro Nakanishi, Shingo Akimoto, Kimio Yoshimura, Minoru Takagi, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p < 0.001), infiltrative growth (p < 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p < 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p < 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p < 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.

Original languageEnglish
Pages (from-to)318-326
Number of pages9
JournalOncology
Volume62
Issue number4
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Tongue
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Neoplasms
Growth
kalinin
Intercellular Signaling Peptides and Proteins
Cytoplasm
Multivariate Analysis
Cell Membrane
Neoplasm Metastasis

Keywords

  • Epidermal growth factor receptor
  • Immunohistochemistry
  • Laminin-5 γ2 chain
  • Squamous cell carcinoma
  • Tongue

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Correlation between laminin-5 γ2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue. / Katoh, Kazuhide; Nakanishi, Yukihiro; Akimoto, Shingo; Yoshimura, Kimio; Takagi, Minoru; Sakamoto, Michiie; Hirohashi, Setsuo.

In: Oncology, Vol. 62, No. 4, 2002, p. 318-326.

Research output: Contribution to journalArticle

@article{dac32cac4de349af8b0b7ff1e347d7ee,
title = "Correlation between laminin-5 γ2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue",
abstract = "Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p < 0.001), infiltrative growth (p < 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p < 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p < 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p < 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.",
keywords = "Epidermal growth factor receptor, Immunohistochemistry, Laminin-5 γ2 chain, Squamous cell carcinoma, Tongue",
author = "Kazuhide Katoh and Yukihiro Nakanishi and Shingo Akimoto and Kimio Yoshimura and Minoru Takagi and Michiie Sakamoto and Setsuo Hirohashi",
year = "2002",
doi = "10.1159/000065063",
language = "English",
volume = "62",
pages = "318--326",
journal = "Oncology (Switzerland)",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Correlation between laminin-5 γ2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue

AU - Katoh, Kazuhide

AU - Nakanishi, Yukihiro

AU - Akimoto, Shingo

AU - Yoshimura, Kimio

AU - Takagi, Minoru

AU - Sakamoto, Michiie

AU - Hirohashi, Setsuo

PY - 2002

Y1 - 2002

N2 - Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p < 0.001), infiltrative growth (p < 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p < 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p < 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p < 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.

AB - Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p < 0.001), infiltrative growth (p < 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p < 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p < 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p < 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.

KW - Epidermal growth factor receptor

KW - Immunohistochemistry

KW - Laminin-5 γ2 chain

KW - Squamous cell carcinoma

KW - Tongue

UR - http://www.scopus.com/inward/record.url?scp=0036055766&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036055766&partnerID=8YFLogxK

U2 - 10.1159/000065063

DO - 10.1159/000065063

M3 - Article

C2 - 12138239

AN - SCOPUS:0036055766

VL - 62

SP - 318

EP - 326

JO - Oncology (Switzerland)

JF - Oncology (Switzerland)

SN - 0030-2414

IS - 4

ER -