Abstract
Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p < 0.001), infiltrative growth (p < 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p < 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p < 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p < 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.
| Original language | English |
|---|---|
| Pages (from-to) | 318-326 |
| Number of pages | 9 |
| Journal | Oncology |
| Volume | 62 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2002 |
| Externally published | Yes |
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Keywords
- Epidermal growth factor receptor
- Immunohistochemistry
- Laminin-5 γ2 chain
- Squamous cell carcinoma
- Tongue
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Correlation between laminin-5 γ2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue. / Katoh, Kazuhide; Nakanishi, Yukihiro; Akimoto, Shingo; Yoshimura, Kimio; Takagi, Minoru; Sakamoto, Michiie; Hirohashi, Setsuo.
In: Oncology, Vol. 62, No. 4, 2002, p. 318-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation between laminin-5 γ2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue
AU - Katoh, Kazuhide
AU - Nakanishi, Yukihiro
AU - Akimoto, Shingo
AU - Yoshimura, Kimio
AU - Takagi, Minoru
AU - Sakamoto, Michiie
AU - Hirohashi, Setsuo
PY - 2002
Y1 - 2002
N2 - Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p < 0.001), infiltrative growth (p < 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p < 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p < 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p < 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.
AB - Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p < 0.001), infiltrative growth (p < 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p < 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p < 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p < 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.
KW - Epidermal growth factor receptor
KW - Immunohistochemistry
KW - Laminin-5 γ2 chain
KW - Squamous cell carcinoma
KW - Tongue
UR - http://www.scopus.com/inward/record.url?scp=0036055766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036055766&partnerID=8YFLogxK
U2 - 10.1159/000065063
DO - 10.1159/000065063
M3 - Article
C2 - 12138239
AN - SCOPUS:0036055766
VL - 62
SP - 318
EP - 326
JO - Oncology (Switzerland)
JF - Oncology (Switzerland)
SN - 0030-2414
IS - 4
ER -