Correlation between MIB-1 staining indices and recurrence in low-grade astrocytomas.

M. Hoshi, Kazunari Yoshida, K. Shimazaki, Hikaru Sasaki, M. Otani, T. Kawase

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Abstract

Although low-grade astrocytomas are histologically benign, some of them recur frequently. We retrospectively investigated the relationship between MIB-1 staining index (SI) and recurrence in 47 low-grade astrocytomas that were treated in Keio University Hospital from 1981 to 1991. We found a correlation between SI and recurrence. MIB-1 SIs recurrent low-grade astrocytomas have been shown to be almost similar to those of astrocytoma grade 3. We concluded that it was very important to examine MIB-1 SI in all astrocytomas especially in low-grade astrocytomas, because MIB-1 SI is one of the factors from which we could predict-recurrence and decide whether radiotherapy or chemotherapy should be performed.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalBrain Tumor Pathology
Volume14
Issue number1
Publication statusPublished - 1997

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Astrocytoma
Staining and Labeling
Recurrence
Radiotherapy
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine

Cite this

Correlation between MIB-1 staining indices and recurrence in low-grade astrocytomas. / Hoshi, M.; Yoshida, Kazunari; Shimazaki, K.; Sasaki, Hikaru; Otani, M.; Kawase, T.

In: Brain Tumor Pathology, Vol. 14, No. 1, 1997, p. 47-51.

Research output: Contribution to journalArticle

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AU - Kawase, T.

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