Correlation between serum resistin level and adiposity in obese individuals

Koichiro Azuma, Fuminori Katsukawa, Shuji Oguchi, Mitsuru Murata, Hajime Yamazaki, Akira Shimada, Takao Saruta

Research output: Contribution to journalArticle

275 Citations (Scopus)

Abstract

Objective: Resistin is associated with insulin resistance in mice and may play a similar role in humans. The aim of our study was to examine the relationship of serum resistin level to body composition, insulin resistance, and related obesity phenotypes in humans. Research Methods and Procedures: Sixty-four young (age 32 ± 10 years), obese (BMI 32.9 ± 5.6), nondiabetic subjects taking no medication, and 15 lean (BMI 21.1 ± 1.3) volunteers were studied cross-sectionally. Thirty-five of the subjects were also reevaluated after 1.5 years on a weight reduction program entailing dieting and exercise; changes of serum resistin were compared with changes of BMI, body composition, fat distribution, and several indices of insulin sensitivity derived from plasma glucose and serum insulin levels measured during 75-g oral glucose tolerance test. Results: In a cross-sectional analysis, serum resistin was significantly higher in obese subjects than in lean volunteers (24.58 ± 12.93 ng/mL; n = 64 vs. 12.83 ± 8.30 ng/mL; n = 15; p < 0.01), and there was a correlation between resistin level and BMI, when the two groups were combined (p = 0.35, p < 0.01). Although cross-sectional analysis in obese subjects revealed no correlation between serum resistin and parameters related to adiposity or insulin resistance, longitudinal analysis revealed change in serum resistin to be positively correlated with changes in BMI, body fat, fat mass, visceral fat area, and mean glucose and insulin (p = 0.39, 0.40, 0.44, 0.50, 0.40, and 0.50; p = 0.02, 0.03, 0.02, <0.01, 0.02, and <0.01, respectively). Discussion: Resistin appears to be related to human adiposity and to be a possible candidate factor in human insulin resistance.

Original languageEnglish
Pages (from-to)997-1001
Number of pages5
JournalObesity Research
Volume11
Issue number8
Publication statusPublished - 2003

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resistin
Resistin
Adiposity
adiposity
insulin resistance
Insulin Resistance
Serum
Body Composition
cross-sectional studies
volunteers
body composition
Volunteers
insulin
Cross-Sectional Studies
Insulin
weight control programs
Weight Reduction Programs
Body Fat Distribution
Glucose
visceral fat

Keywords

  • Adiposity
  • Body composition
  • Insulin resistance
  • Mean insulin
  • Resistin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A., & Saruta, T. (2003). Correlation between serum resistin level and adiposity in obese individuals. Obesity Research, 11(8), 997-1001.

Correlation between serum resistin level and adiposity in obese individuals. / Azuma, Koichiro; Katsukawa, Fuminori; Oguchi, Shuji; Murata, Mitsuru; Yamazaki, Hajime; Shimada, Akira; Saruta, Takao.

In: Obesity Research, Vol. 11, No. 8, 2003, p. 997-1001.

Research output: Contribution to journalArticle

Azuma, K, Katsukawa, F, Oguchi, S, Murata, M, Yamazaki, H, Shimada, A & Saruta, T 2003, 'Correlation between serum resistin level and adiposity in obese individuals', Obesity Research, vol. 11, no. 8, pp. 997-1001.
Azuma, Koichiro ; Katsukawa, Fuminori ; Oguchi, Shuji ; Murata, Mitsuru ; Yamazaki, Hajime ; Shimada, Akira ; Saruta, Takao. / Correlation between serum resistin level and adiposity in obese individuals. In: Obesity Research. 2003 ; Vol. 11, No. 8. pp. 997-1001.
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AB - Objective: Resistin is associated with insulin resistance in mice and may play a similar role in humans. The aim of our study was to examine the relationship of serum resistin level to body composition, insulin resistance, and related obesity phenotypes in humans. Research Methods and Procedures: Sixty-four young (age 32 ± 10 years), obese (BMI 32.9 ± 5.6), nondiabetic subjects taking no medication, and 15 lean (BMI 21.1 ± 1.3) volunteers were studied cross-sectionally. Thirty-five of the subjects were also reevaluated after 1.5 years on a weight reduction program entailing dieting and exercise; changes of serum resistin were compared with changes of BMI, body composition, fat distribution, and several indices of insulin sensitivity derived from plasma glucose and serum insulin levels measured during 75-g oral glucose tolerance test. Results: In a cross-sectional analysis, serum resistin was significantly higher in obese subjects than in lean volunteers (24.58 ± 12.93 ng/mL; n = 64 vs. 12.83 ± 8.30 ng/mL; n = 15; p < 0.01), and there was a correlation between resistin level and BMI, when the two groups were combined (p = 0.35, p < 0.01). Although cross-sectional analysis in obese subjects revealed no correlation between serum resistin and parameters related to adiposity or insulin resistance, longitudinal analysis revealed change in serum resistin to be positively correlated with changes in BMI, body fat, fat mass, visceral fat area, and mean glucose and insulin (p = 0.39, 0.40, 0.44, 0.50, 0.40, and 0.50; p = 0.02, 0.03, 0.02, <0.01, 0.02, and <0.01, respectively). Discussion: Resistin appears to be related to human adiposity and to be a possible candidate factor in human insulin resistance.

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