Correlation of a decline in aerobic capacity with development of emphysema in patients with chronic obstructive pulmonary disease

A prospective observational study

Wakako Yamasawa, Sadatomo Tasaka, Tomoko Betsuyaku, Kazuhiro Yamaguchi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In patients with COPD, CT assessment of emphysema and airway disease is known to be associated with lung function and 6-minute walk distance. However, it remains to be determined whether low attenuation area (LAA) on CT is associated with aerobic capacity assessed using cardiopulmonary exercise testing (CPET). In this prospective observational study, we repeatedly conducted high-resolution CT and CPET using a treadmill in 81 COPD patients over a median interval of 3.5 years. Two investigators independently scored LAA on images obtained at the aortic arch level, tracheal bifurcation level, and supradiaphragmatic level. Grades for the images of each lung were added to yield the total LAA score. Total LAA score was negatively correlated with peak aerobic capacity (VO<inf>2</inf> )(p<0.001, r = -0.485). LAA scores of the upper (aortic arch level) and the lower (supradiaphragmatic level) lungs were both significantly associated with peak VO<inf>2</inf>. There was a significant correlation between total LAA score and peak CO<inf>2</inf> output (VCO<inf>2</inf>)(p<0.001, r = -0.433). Total LAA score was correlated with oxygen saturation at peak exercise (p<0.001, r = -0.634) and the estimated dead space fraction (p<0.001, r = 0.416). The mean annual change in total LAA score was significantly correlated with those in peak VO<inf>2</inf> (p<0.001, r = -0.546) and peak VCO<inf>2</inf> (p<0.001, r = -0.488). The extent of emphysema measured by CT was associated with the results of CPET. The time-dependent changes in CPET data were also correlated with that in total LAA score. CT assessment could be a non-invasive tool to predict aerobic capacity in patients with COPD.

Original languageEnglish
Article numbere0125053
JournalPLoS One
Volume10
Issue number4
DOIs
Publication statusPublished - 2015 Apr 24

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Pulmonary diseases
exercise test
Emphysema
observational studies
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
Observational Studies
Prospective Studies
Exercise
Testing
Exercise equipment
Lung
lung function
exercise equipment
Arches
Thoracic Aorta
lungs
Research Personnel

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Correlation of a decline in aerobic capacity with development of emphysema in patients with chronic obstructive pulmonary disease : A prospective observational study. / Yamasawa, Wakako; Tasaka, Sadatomo; Betsuyaku, Tomoko; Yamaguchi, Kazuhiro.

In: PLoS One, Vol. 10, No. 4, e0125053, 24.04.2015.

Research output: Contribution to journalArticle

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