Correlation of antithrombogenicity and heat treatment for layer-by-layer self-assembled polyelectrolyte films

Motomi Matsuda, Seimei Shiratori

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Antithrombogenic films with high durability were fabricated in a wet process. Antithrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid) (PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming cross-links via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. The antithrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 min, whereas with uncoated mesh blood flow stopped within 6 min because of blood vessel blockage by thrombus formation.

Original languageEnglish
Pages (from-to)4271-4277
Number of pages7
JournalLangmuir
Volume27
Issue number7
DOIs
Publication statusPublished - 2011 Apr 5

Fingerprint

Polyelectrolytes
heat treatment
Heat treatment
mesh
carbopol 940
blood vessels
Blood vessels
blood flow
durability
Durability
Blood
abrasion resistance
fibrinogen
swine
Multilayer films
Stainless Steel
hydrochlorides
acrylic acid
polycyclic aromatic hydrocarbons
Polycyclic aromatic hydrocarbons

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Correlation of antithrombogenicity and heat treatment for layer-by-layer self-assembled polyelectrolyte films. / Matsuda, Motomi; Shiratori, Seimei.

In: Langmuir, Vol. 27, No. 7, 05.04.2011, p. 4271-4277.

Research output: Contribution to journalArticle

Matsuda, Motomi ; Shiratori, Seimei. / Correlation of antithrombogenicity and heat treatment for layer-by-layer self-assembled polyelectrolyte films. In: Langmuir. 2011 ; Vol. 27, No. 7. pp. 4271-4277.
@article{1fd46d4a947949e2b984453be31206de,
title = "Correlation of antithrombogenicity and heat treatment for layer-by-layer self-assembled polyelectrolyte films",
abstract = "Antithrombogenic films with high durability were fabricated in a wet process. Antithrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid) (PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming cross-links via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. The antithrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 min, whereas with uncoated mesh blood flow stopped within 6 min because of blood vessel blockage by thrombus formation.",
author = "Motomi Matsuda and Seimei Shiratori",
year = "2011",
month = "4",
day = "5",
doi = "10.1021/la200340v",
language = "English",
volume = "27",
pages = "4271--4277",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "7",

}

TY - JOUR

T1 - Correlation of antithrombogenicity and heat treatment for layer-by-layer self-assembled polyelectrolyte films

AU - Matsuda, Motomi

AU - Shiratori, Seimei

PY - 2011/4/5

Y1 - 2011/4/5

N2 - Antithrombogenic films with high durability were fabricated in a wet process. Antithrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid) (PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming cross-links via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. The antithrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 min, whereas with uncoated mesh blood flow stopped within 6 min because of blood vessel blockage by thrombus formation.

AB - Antithrombogenic films with high durability were fabricated in a wet process. Antithrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid) (PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming cross-links via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. The antithrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 min, whereas with uncoated mesh blood flow stopped within 6 min because of blood vessel blockage by thrombus formation.

UR - http://www.scopus.com/inward/record.url?scp=79953252988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953252988&partnerID=8YFLogxK

U2 - 10.1021/la200340v

DO - 10.1021/la200340v

M3 - Article

C2 - 21381714

AN - SCOPUS:79953252988

VL - 27

SP - 4271

EP - 4277

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 7

ER -