Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor

Sumio Ohtsuki, Mayu Kamoi, Yuki Watanabe, Hiroya Suzuki, Satoko Hori, Tetsuya Terasaki

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The ATP binding cassette transporter subtype A5 (ABCA5)-like transporters ABCA5, ABCA6, ABCA8, ABCA9 and ABCA10 form a unique gene cluster within the ABC transporter superfamily, though their function is still poorly understood. The purpose of this study is to examine whether ABCA5-like transporters may play a role in tumor development by measuring their mRNA levels in human tissues and tumors. Intense mRNA expression of human ABCA5-like transporters was detected in the brain. ABCA5 and ABCA8 mRNAs were detected in spleen, testis and ovary. ABCA5 mRNA was also detected in liver and pancreas. ABCA6 mRNA was detected in lung and liver, and ABCA8 was detected in lung. ABCA6, ABCA7 and ABCA8 mRNAs were not detected in any tumors, but weak mRNA expression of ABCA10 was detected in all tumors examined. ABCA5 mRNA was detected in poorly differentiated colon adenocarcinoma (GI-112) and undifferentiated ovarian carcinoma (GI-102), but not in normal colon. ABCB1 mRNA was also detected in GI-112, while ABCC1 and ABCA2 mRNAs were not. In contrast, ABCC1 and ABCA2 mRNAs, but not ABCA5 or ABCB1 mRNA, were detected in well differentiated colon adenocarcinoma (CX-1). Thus, induction of ABCA5, together with ABCB1, appears to be correlated with the differentiation state of human colon tumors, and may have a role in tumor development.

Original languageEnglish
Pages (from-to)1144-1146
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1
Externally publishedYes

Fingerprint

ATP-Binding Cassette Transporters
Colon
Messenger RNA
Neoplasms
Adenocarcinoma
Lung
Liver
Multigene Family
Testis
Pancreas
Ovary
Spleen

Keywords

  • ABC transporter A5 (ABCA5)
  • ATP binding cassette (ABC) transporter
  • Colon adenocarcinoma
  • mRNA expression
  • Tumor

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor. / Ohtsuki, Sumio; Kamoi, Mayu; Watanabe, Yuki; Suzuki, Hiroya; Hori, Satoko; Terasaki, Tetsuya.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 6, 01.06.2007, p. 1144-1146.

Research output: Contribution to journalArticle

Ohtsuki, Sumio ; Kamoi, Mayu ; Watanabe, Yuki ; Suzuki, Hiroya ; Hori, Satoko ; Terasaki, Tetsuya. / Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor. In: Biological and Pharmaceutical Bulletin. 2007 ; Vol. 30, No. 6. pp. 1144-1146.
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