Abstract
As human papillomavirus (HPV) infection is the main risk factor for squamous cell carcinoma of the cervix and overexpression of p16INK4a occurs when retinoblastoma protein is inactivated by high-risk HPV, the authors studied the association of HPV infection and expression of p16INK4a in cervical adenocarcinomas. Specimens of cervical glandular neoplasias were immunostained with a p16INK4a-specific monoclonal antibody (clone E6H4). Approximately 80% of glandular neoplasms showed overexpression of p16INK4a. Exfoliated cells from 14 adenocarcinomas were further examined by p16INK4a-specific immunocytochemistry, and 12 cases showed overexpression of p16INK4a, suggesting that immunostaining for p16INK4a may be a useful diagnostic tool for cervical adenocarcinomas. The authors further examined HPV DNA in cervical adenocarcinomas with the polymerase chain reaction method. Overexpression of p16INK4a was positive in 94% of cases in which HPV16 or 18DNA was positive, a finding suggesting that HPV16 or 18 may play an important role in cervical adenocarcinomas. Overexpression of p16INK4a may be an indicator of pathogenic activity of high-risk HPVs.
Original language | English |
---|---|
Pages (from-to) | 378-385 |
Number of pages | 8 |
Journal | International Journal of Gynecological Pathology |
Volume | 22 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2003 Oct 1 |
Keywords
- Adenocarcinoma
- Human papillomavirus
- P16
- Uterine cervix
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Obstetrics and Gynaecology