Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer

Mitsuhiro Fujishiro, M. Oka, Naohisa Yahagi, M. Nakamura, N. Kakushima, S. Kodashima, K. Kobayashi, T. Hashimoto, N. Yamamichi, Y. Moriyama, A. Tateishi, S. Ono, Y. Shimizu, M. Ichinose, K. Miki, M. Omata

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The correlation between serum pepsinogen (PG) levels and the gross types was investigated in 128 consecutive patients with early gastric cancer. Although there was no significant difference in age, gender, cancer location, or cancer depth among gross appearances, the distribution of histological type was significantly different between polypoid and depressed cancers: all polypoid cancers except one were intestinal type, whereas nearly a third of depressed cancers were diffuse type. All the patients in whom Helicobacter pylori status was investigated had Helicobacter pylori infection. Combination of gross appearances and histology (polypoid cancer with intestinal type, depressed cancer with intestinal type and depressed cancer with diffuse type) showed a clear difference in distribution of serum PG levels and a ratio between levels of PG I and PG II (I/II ratio). In polypoid cancer with intestinal type, a PG I level and a I/II ratio were significantly lower than those of the others. In depressed cancer with diffuse type, PG I and PG II levels were significantly higher. These findings revealed that backgrounds such as intragastric acidity and extent of gastric atrophy might differ among early gastric cancers with different morphology and histology.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Volume25
Issue number2
Publication statusPublished - 2006 Jun
Externally publishedYes

Fingerprint

Pepsinogens
Pepsinogen A
Stomach Neoplasms
Histology
Intestinal Neoplasms
Serum
Pepsinogen C
Neoplasms
Helicobacter pylori
Helicobacter Infections
Atrophy
Stomach

Keywords

  • Early gastric cancer
  • Gross type
  • Histological type
  • Pepsinogen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer. / Fujishiro, Mitsuhiro; Oka, M.; Yahagi, Naohisa; Nakamura, M.; Kakushima, N.; Kodashima, S.; Kobayashi, K.; Hashimoto, T.; Yamamichi, N.; Moriyama, Y.; Tateishi, A.; Ono, S.; Shimizu, Y.; Ichinose, M.; Miki, K.; Omata, M.

In: Journal of Experimental and Clinical Cancer Research, Vol. 25, No. 2, 06.2006, p. 207-212.

Research output: Contribution to journalArticle

Fujishiro, M, Oka, M, Yahagi, N, Nakamura, M, Kakushima, N, Kodashima, S, Kobayashi, K, Hashimoto, T, Yamamichi, N, Moriyama, Y, Tateishi, A, Ono, S, Shimizu, Y, Ichinose, M, Miki, K & Omata, M 2006, 'Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer', Journal of Experimental and Clinical Cancer Research, vol. 25, no. 2, pp. 207-212.
Fujishiro, Mitsuhiro ; Oka, M. ; Yahagi, Naohisa ; Nakamura, M. ; Kakushima, N. ; Kodashima, S. ; Kobayashi, K. ; Hashimoto, T. ; Yamamichi, N. ; Moriyama, Y. ; Tateishi, A. ; Ono, S. ; Shimizu, Y. ; Ichinose, M. ; Miki, K. ; Omata, M. / Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer. In: Journal of Experimental and Clinical Cancer Research. 2006 ; Vol. 25, No. 2. pp. 207-212.
@article{a83c9fffbabf497faa487e095afb796e,
title = "Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer",
abstract = "The correlation between serum pepsinogen (PG) levels and the gross types was investigated in 128 consecutive patients with early gastric cancer. Although there was no significant difference in age, gender, cancer location, or cancer depth among gross appearances, the distribution of histological type was significantly different between polypoid and depressed cancers: all polypoid cancers except one were intestinal type, whereas nearly a third of depressed cancers were diffuse type. All the patients in whom Helicobacter pylori status was investigated had Helicobacter pylori infection. Combination of gross appearances and histology (polypoid cancer with intestinal type, depressed cancer with intestinal type and depressed cancer with diffuse type) showed a clear difference in distribution of serum PG levels and a ratio between levels of PG I and PG II (I/II ratio). In polypoid cancer with intestinal type, a PG I level and a I/II ratio were significantly lower than those of the others. In depressed cancer with diffuse type, PG I and PG II levels were significantly higher. These findings revealed that backgrounds such as intragastric acidity and extent of gastric atrophy might differ among early gastric cancers with different morphology and histology.",
keywords = "Early gastric cancer, Gross type, Histological type, Pepsinogen",
author = "Mitsuhiro Fujishiro and M. Oka and Naohisa Yahagi and M. Nakamura and N. Kakushima and S. Kodashima and K. Kobayashi and T. Hashimoto and N. Yamamichi and Y. Moriyama and A. Tateishi and S. Ono and Y. Shimizu and M. Ichinose and K. Miki and M. Omata",
year = "2006",
month = "6",
language = "English",
volume = "25",
pages = "207--212",
journal = "Journal of Experimental and Clinical Cancer Research",
issn = "0392-9078",
publisher = "BioMed Central",
number = "2",

}

TY - JOUR

T1 - Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer

AU - Fujishiro, Mitsuhiro

AU - Oka, M.

AU - Yahagi, Naohisa

AU - Nakamura, M.

AU - Kakushima, N.

AU - Kodashima, S.

AU - Kobayashi, K.

AU - Hashimoto, T.

AU - Yamamichi, N.

AU - Moriyama, Y.

AU - Tateishi, A.

AU - Ono, S.

AU - Shimizu, Y.

AU - Ichinose, M.

AU - Miki, K.

AU - Omata, M.

PY - 2006/6

Y1 - 2006/6

N2 - The correlation between serum pepsinogen (PG) levels and the gross types was investigated in 128 consecutive patients with early gastric cancer. Although there was no significant difference in age, gender, cancer location, or cancer depth among gross appearances, the distribution of histological type was significantly different between polypoid and depressed cancers: all polypoid cancers except one were intestinal type, whereas nearly a third of depressed cancers were diffuse type. All the patients in whom Helicobacter pylori status was investigated had Helicobacter pylori infection. Combination of gross appearances and histology (polypoid cancer with intestinal type, depressed cancer with intestinal type and depressed cancer with diffuse type) showed a clear difference in distribution of serum PG levels and a ratio between levels of PG I and PG II (I/II ratio). In polypoid cancer with intestinal type, a PG I level and a I/II ratio were significantly lower than those of the others. In depressed cancer with diffuse type, PG I and PG II levels were significantly higher. These findings revealed that backgrounds such as intragastric acidity and extent of gastric atrophy might differ among early gastric cancers with different morphology and histology.

AB - The correlation between serum pepsinogen (PG) levels and the gross types was investigated in 128 consecutive patients with early gastric cancer. Although there was no significant difference in age, gender, cancer location, or cancer depth among gross appearances, the distribution of histological type was significantly different between polypoid and depressed cancers: all polypoid cancers except one were intestinal type, whereas nearly a third of depressed cancers were diffuse type. All the patients in whom Helicobacter pylori status was investigated had Helicobacter pylori infection. Combination of gross appearances and histology (polypoid cancer with intestinal type, depressed cancer with intestinal type and depressed cancer with diffuse type) showed a clear difference in distribution of serum PG levels and a ratio between levels of PG I and PG II (I/II ratio). In polypoid cancer with intestinal type, a PG I level and a I/II ratio were significantly lower than those of the others. In depressed cancer with diffuse type, PG I and PG II levels were significantly higher. These findings revealed that backgrounds such as intragastric acidity and extent of gastric atrophy might differ among early gastric cancers with different morphology and histology.

KW - Early gastric cancer

KW - Gross type

KW - Histological type

KW - Pepsinogen

UR - http://www.scopus.com/inward/record.url?scp=33746328672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746328672&partnerID=8YFLogxK

M3 - Article

C2 - 16918132

AN - SCOPUS:33746328672

VL - 25

SP - 207

EP - 212

JO - Journal of Experimental and Clinical Cancer Research

JF - Journal of Experimental and Clinical Cancer Research

SN - 0392-9078

IS - 2

ER -