TY - JOUR
T1 - Correlation of the endoscopic and magnetic resonance scoring systems in the deep small intestine in Crohn's disease
AU - Takenaka, Kento
AU - Ohtsuka, Kazuo
AU - Kitazume, Yoshio
AU - Nagahori, Masakazu
AU - Fujii, Toshimitsu
AU - Saito, Eiko
AU - Fujioka, Tomoyuki
AU - Matsuoka, Katsuyoshi
AU - Naganuma, Makoto
AU - Watanabe, Mamoru
N1 - Publisher Copyright:
Copyright © 2015 Crohn's & Colitis Foundation of America, Inc.
PY - 2015/4/29
Y1 - 2015/4/29
N2 - Background: There are no widely accepted endoscopic or magnetic resonance scoring systems to evaluate deep small intestinal lesions in Crohn's disease (CD). This study aimed to determine whether the simplified endoscopic activity score for Crohn's disease (SES-CD) and the Magnetic Resonance Index of Activity (MaRIA) could be adapted for assessing CD lesions in the deep small intestine. Methods: Magnetic resonance enterocolonography and single-balloon enteroscopy were prospectively performed in 125 patients with CD. SES-CD and MaRIA were applied to the deep small intestine. The correlation between the SES-CD and MaRIA was evaluated. Results: Endoscopic and magnetic resonance active lesions were detected in the terminal and proximal ileal segments at a similar rate. The total MaRIA scores correlated well with the total SES-CD scores (R = 0.808, P < 0.001). A MaRIA score of ≥11 had a high sensitivity, specificity, and diagnostic accuracy for ulcerative lesions that were defined by enteroscopy (sensitivity: 78.3%; specificity: 98.0%). Similarly, an MaRIA score of ≥7 had a high sensitivity, specificity, and diagnostic accuracy for all mucosal lesions defined by enteroscopy (sensitivity: 87.0%; specificity: 86.0%). Conclusions: The MaRIA closely correlates with the SES-CD in the deep small intestine, indicating these scoring systems can be used to assess deep small intestinal lesions. We also showed the validity of MaRIA to evaluate the active lesions in the deep small intestine.
AB - Background: There are no widely accepted endoscopic or magnetic resonance scoring systems to evaluate deep small intestinal lesions in Crohn's disease (CD). This study aimed to determine whether the simplified endoscopic activity score for Crohn's disease (SES-CD) and the Magnetic Resonance Index of Activity (MaRIA) could be adapted for assessing CD lesions in the deep small intestine. Methods: Magnetic resonance enterocolonography and single-balloon enteroscopy were prospectively performed in 125 patients with CD. SES-CD and MaRIA were applied to the deep small intestine. The correlation between the SES-CD and MaRIA was evaluated. Results: Endoscopic and magnetic resonance active lesions were detected in the terminal and proximal ileal segments at a similar rate. The total MaRIA scores correlated well with the total SES-CD scores (R = 0.808, P < 0.001). A MaRIA score of ≥11 had a high sensitivity, specificity, and diagnostic accuracy for ulcerative lesions that were defined by enteroscopy (sensitivity: 78.3%; specificity: 98.0%). Similarly, an MaRIA score of ≥7 had a high sensitivity, specificity, and diagnostic accuracy for all mucosal lesions defined by enteroscopy (sensitivity: 87.0%; specificity: 86.0%). Conclusions: The MaRIA closely correlates with the SES-CD in the deep small intestine, indicating these scoring systems can be used to assess deep small intestinal lesions. We also showed the validity of MaRIA to evaluate the active lesions in the deep small intestine.
KW - Crohn's disease
KW - Diagnosis
KW - Endoscopy
KW - MR
UR - http://www.scopus.com/inward/record.url?scp=84946921920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946921920&partnerID=8YFLogxK
U2 - 10.1097/MIB.0000000000000449
DO - 10.1097/MIB.0000000000000449
M3 - Article
C2 - 26020602
AN - SCOPUS:84946921920
SN - 1078-0998
VL - 21
SP - 1832
EP - 1838
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
IS - 8
ER -