Abstract
A 62-year-old woman initially presented with slowly progressive nonfluent aphasia with minimal intellectual involvement. Echolalia and personality change were prominent whereas parkinsonian features and signs suggesting parietal lobe dysfunctions were not present. The patient's language deficit was consistent with transcortical motor aphasia. She did not manifest extrapyramidal signs. The patient was diagnosed as having Pick's disease or frontal lobe dementia. She died at age 65, 2 years and 9 months following disease onset. Neuropathological findings including cytoskeletal abnormalities, however, were clearly distinct from those of classical Pick's disease and were consistent with those reported in corticobasal degeneration (CBD). The distribution of her cortical lesions was accentuated in the frontal language-related area. The clinical manifestations in CBD are diverse, and primary progressive nonfluent aphasia should be considered as an initial symptom of CBD. Neuropathological examination of such patients should include cytoskeletal abnormality studies.
| Original language | English |
|---|---|
| Pages (from-to) | 19-26 |
| Number of pages | 8 |
| Journal | Journal of the Neurological Sciences |
| Volume | 183 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2001 Jan 15 |
| Externally published | Yes |
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Keywords
- Corticobasal degeneration
- Cytoskeletal abnormality
- Frontal lobe dementia
- Nonfluent aphasia
- Pick's disease
- Primary progressive aphasia
ASJC Scopus subject areas
- Ageing
- Clinical Neurology
- Surgery
- Developmental Neuroscience
- Neurology
- Neuroscience(all)
Cite this
Corticobasal degeneration presenting with nonfluent primary progressive aphasia : A clinicopathological study. / Mimura, Masaru; Oda, Tatsuro; Tsuchiya, Kuniaki; Kato, Motoichiro; Ikeda, Kenji; Hori, Koji; Kashima, Haruo.
In: Journal of the Neurological Sciences, Vol. 183, No. 1, 15.01.2001, p. 19-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Corticobasal degeneration presenting with nonfluent primary progressive aphasia
T2 - A clinicopathological study
AU - Mimura, Masaru
AU - Oda, Tatsuro
AU - Tsuchiya, Kuniaki
AU - Kato, Motoichiro
AU - Ikeda, Kenji
AU - Hori, Koji
AU - Kashima, Haruo
PY - 2001/1/15
Y1 - 2001/1/15
N2 - A 62-year-old woman initially presented with slowly progressive nonfluent aphasia with minimal intellectual involvement. Echolalia and personality change were prominent whereas parkinsonian features and signs suggesting parietal lobe dysfunctions were not present. The patient's language deficit was consistent with transcortical motor aphasia. She did not manifest extrapyramidal signs. The patient was diagnosed as having Pick's disease or frontal lobe dementia. She died at age 65, 2 years and 9 months following disease onset. Neuropathological findings including cytoskeletal abnormalities, however, were clearly distinct from those of classical Pick's disease and were consistent with those reported in corticobasal degeneration (CBD). The distribution of her cortical lesions was accentuated in the frontal language-related area. The clinical manifestations in CBD are diverse, and primary progressive nonfluent aphasia should be considered as an initial symptom of CBD. Neuropathological examination of such patients should include cytoskeletal abnormality studies.
AB - A 62-year-old woman initially presented with slowly progressive nonfluent aphasia with minimal intellectual involvement. Echolalia and personality change were prominent whereas parkinsonian features and signs suggesting parietal lobe dysfunctions were not present. The patient's language deficit was consistent with transcortical motor aphasia. She did not manifest extrapyramidal signs. The patient was diagnosed as having Pick's disease or frontal lobe dementia. She died at age 65, 2 years and 9 months following disease onset. Neuropathological findings including cytoskeletal abnormalities, however, were clearly distinct from those of classical Pick's disease and were consistent with those reported in corticobasal degeneration (CBD). The distribution of her cortical lesions was accentuated in the frontal language-related area. The clinical manifestations in CBD are diverse, and primary progressive nonfluent aphasia should be considered as an initial symptom of CBD. Neuropathological examination of such patients should include cytoskeletal abnormality studies.
KW - Corticobasal degeneration
KW - Cytoskeletal abnormality
KW - Frontal lobe dementia
KW - Nonfluent aphasia
KW - Pick's disease
KW - Primary progressive aphasia
UR - http://www.scopus.com/inward/record.url?scp=0035862772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035862772&partnerID=8YFLogxK
U2 - 10.1016/S0022-510X(00)00470-6
DO - 10.1016/S0022-510X(00)00470-6
M3 - Article
C2 - 11166789
AN - SCOPUS:0035862772
VL - 183
SP - 19
EP - 26
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1
ER -