Cosecretion of peptides derived from gamma-human atrial natriuretic polypeptide in normal volunteers and patients with essential hypertension and adrenal disorders

Akira Sugawara, Kazuwa Nakao, Hiroshi Itoh, Takayuki Yamada, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Gotaro Shirakami, Narito Morii, Shozo Shiono, Hiroo Imura

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Using two radio-immunoassays for N-terminal and C-terminal fragments of human atrial natriuretic polypeptide (ANP) precursor, γ-hANP [human atrial natriuretic factor- (1-126)], that is γ -hANP(1-25) [human atrial natriuretic factor-(1-25)] and α-hANP [human atrial natriuretic factor-(99-126)], we studied the secretion of γ -hANP-derived peptides into circulation from the heart in normal subjects and patients with essential hypertension and adrenal disorders. Volume expansion with 2 litres physiological saline increased plasma γ -hANP(1-25)-like immunoreactivity concomitantly with plasma α - hANP-like immunoreactivity in normal subjects. Infusion of angiotensin II (20 ng/kg per min) or noradrenaline (200 ng/kg per min) also caused a parallel increase in plasma γ -hANP(1-25)-like and α -hANP-like immunoreactivity. Plasma γ -hANP(1-25)-like immunoreactivity levels were changed together with α -hANP-like immunoreactivity in patients with essential hypertension and adrenal disorders. These results indicate that γ -hANP-derived peptides, α -hANP and the 10-k N- terminal fragment of γ -hANP (N-peptide) are cosecreted from the heart and that the simultaneous measurement of N-peptide and α -hANP serves as an indicator of the cardiac endocrine function. The significance of N-peptide as a hormone must await further clarification.

Original languageEnglish
Pages (from-to)S327-S329
JournalJournal of Hypertension, Supplement
Volume6
Issue number4
DOIs
Publication statusPublished - 1988 Dec
Externally publishedYes

Keywords

  • Adrenal disorders
  • Cosecretion
  • Essential hypertension
  • N-terminal fragment of γ-human atrial natriuretic polypeptide (N-peptide)
  • α-human atrial natriuretic polypeptide
  • γ-human atrial natriuretic polypeptide

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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