Costimulatory molecules as adjuvants for immunotherapy

James W. Hodge, John W. Greiner, Kwong Yok Tsang, Helen Sabzevari, Chie Kudo-Saito, Douglas W. Grosenbach, James L. Gulley, Philip M. Arlen, John L. Marshall, Dennis Panicali, Jeffrey Schlom

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Tumor-associated antigens (TAAs) are by definition either weakly immunogenic or functionally nonimmunogenic. Therefore, efforts have concentrated on the development of vaccine strategies in which the presentation of TAAs to the immune system results in far greater activation of T cells than that occurring naturally in the host. Several strategies are being explored in our laboratory and others to enhance the immunogenicity of TAAs. These are: (a) placing the gene coding for the tumor antigen, as a transgene, into poxvirus vectors. (b) The use of diversified prime and boost vaccine strategies employing two different types of poxvirus vectors. (c) The use of T-cell costimulation; accomplished by placing transgenes for different T-cell costimulation molecules into viral vectors along with the transgenes for the TAA. (d) Altering the amino acid sequence of the TAA to enhance the host immune response. (e) The use of cytokines, and in particular GM-CSF, as a biologic adjuvant. This review will focus on the current state of the use of costimulatory molecules as adjuvants for immunotherapy, and in particular, as immunomodulators for cancer vaccines.

Original languageEnglish
Pages (from-to)788-803
Number of pages16
JournalFrontiers in Bioscience
Volume11
Issue number1 P.447-888
DOIs
Publication statusPublished - 2006 Feb 24

Keywords

  • B7-1
  • Costimulation
  • Fowlpox
  • ICAM-1
  • Immunotherapy
  • LFA-3
  • Review
  • TRICOM
  • Therapeutics
  • Treatment
  • Vaccinia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Hodge, J. W., Greiner, J. W., Tsang, K. Y., Sabzevari, H., Kudo-Saito, C., Grosenbach, D. W., Gulley, J. L., Arlen, P. M., Marshall, J. L., Panicali, D., & Schlom, J. (2006). Costimulatory molecules as adjuvants for immunotherapy. Frontiers in Bioscience, 11(1 P.447-888), 788-803. https://doi.org/10.2741/1837