Covariance structure of neuroticism and agreeableness: A twin and molecular genetic analysis of the role of the serotonin transporter gene

Kerry L. Jang, W. John Livesley, Rainer Riemann, Philip A. Vernon, Stella Hu, Alois Angleitner, Jyukou Andou, Yutaka Ono, Dean H. Hamer

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The Revised NEO Personality Inventory domains of Neuroticism and Agreeableness are considered factorially distinct despite several intercorrelations between these domains. The genetic correlation, an index of the degree to which these intercorrelations are caused by genetic influences, was estimated using data from 913 monozygotic and 562 dizygotic volunteer twin pairs from Canada, Germany, and Japan. The serotonin transporter gene, 5-HTTLPR, was assayed in a sample of 388 nontwin sibling pairs from the United States to determine the contribution of the serotonin transporter locus to the covariation between the Neuroticism and Agreeableness scales. In all four samples, genetic influences contributed to the covariance of Neuroticism and Agreeableness, with the serotonin transporter gene accounting for 10% of the relationship between these domains.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalJournal of Personality and Social Psychology
Volume81
Issue number2
DOIs
Publication statusPublished - 2001 Jan 1

ASJC Scopus subject areas

  • Social Psychology
  • Sociology and Political Science

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