Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations

Shigeki Sekine, Tatsuhiro Shibata, Akiko Kokubu, Yukio Morishita, Masayuki Noguchi, Yukihiro Nakanishi, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Craniopharyngioma is a rare tumor occurring in the sellar region comprising 3% of all intracranial tumors. To elucidate the contribution of β-catenin gene mutation to tumorigenesis, we examined genetic alterations and expression of β-catenin in 10 cases of adamantinomatous and 6 cases of papillary craniopharyngiomas. β-Catenin gene mutations were found in all of the adamantinomatous and none of the papillary craniopharyngiomas. Immunohistochemically, all cases of adamantinomatous craniopharyngioma showed cytoplasmic and nuclear expression of β-catenin. In contrast, papillary craniopharyngiomas showed exclusively membranous expression. The results suggest that adamantinomatous- and papillary-type craniopharyngiomas are not only clinicopathologically, but also genetically, distinctive variants. Mutation of the β-catenin gene therefore seems to play an important role in the tumorigenesis of adamantinomatous craniopharyngioma. Among the adamantinomatous-type tumors, β-catenin-positive mesenchymal cells were observed in two cases. Microdissection-based mutational analysis revealed that these mesenchymal cells also harbor the same β-catenin gene mutations as those of epithelial cells, suggesting their tumorous nature. Thus, at least a subset of adamantinomatous craniopharyngioma is considered to be biphasic.

Original languageEnglish
Pages (from-to)1997-2001
Number of pages5
JournalAmerican Journal of Pathology
Volume161
Issue number6
Publication statusPublished - 2002 Dec 1
Externally publishedYes

Fingerprint

Craniopharyngioma
Catenins
Mutation
Genes
Carcinogenesis
Neoplasms
Microdissection
Epithelial Cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Sekine, S., Shibata, T., Kokubu, A., Morishita, Y., Noguchi, M., Nakanishi, Y., ... Hirohashi, S. (2002). Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. American Journal of Pathology, 161(6), 1997-2001.

Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. / Sekine, Shigeki; Shibata, Tatsuhiro; Kokubu, Akiko; Morishita, Yukio; Noguchi, Masayuki; Nakanishi, Yukihiro; Sakamoto, Michiie; Hirohashi, Setsuo.

In: American Journal of Pathology, Vol. 161, No. 6, 01.12.2002, p. 1997-2001.

Research output: Contribution to journalArticle

Sekine, S, Shibata, T, Kokubu, A, Morishita, Y, Noguchi, M, Nakanishi, Y, Sakamoto, M & Hirohashi, S 2002, 'Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations', American Journal of Pathology, vol. 161, no. 6, pp. 1997-2001.
Sekine S, Shibata T, Kokubu A, Morishita Y, Noguchi M, Nakanishi Y et al. Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. American Journal of Pathology. 2002 Dec 1;161(6):1997-2001.
Sekine, Shigeki ; Shibata, Tatsuhiro ; Kokubu, Akiko ; Morishita, Yukio ; Noguchi, Masayuki ; Nakanishi, Yukihiro ; Sakamoto, Michiie ; Hirohashi, Setsuo. / Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. In: American Journal of Pathology. 2002 ; Vol. 161, No. 6. pp. 1997-2001.
@article{e3f66e92c2a14ad486b9c2c3a6c42112,
title = "Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations",
abstract = "Craniopharyngioma is a rare tumor occurring in the sellar region comprising 3{\%} of all intracranial tumors. To elucidate the contribution of β-catenin gene mutation to tumorigenesis, we examined genetic alterations and expression of β-catenin in 10 cases of adamantinomatous and 6 cases of papillary craniopharyngiomas. β-Catenin gene mutations were found in all of the adamantinomatous and none of the papillary craniopharyngiomas. Immunohistochemically, all cases of adamantinomatous craniopharyngioma showed cytoplasmic and nuclear expression of β-catenin. In contrast, papillary craniopharyngiomas showed exclusively membranous expression. The results suggest that adamantinomatous- and papillary-type craniopharyngiomas are not only clinicopathologically, but also genetically, distinctive variants. Mutation of the β-catenin gene therefore seems to play an important role in the tumorigenesis of adamantinomatous craniopharyngioma. Among the adamantinomatous-type tumors, β-catenin-positive mesenchymal cells were observed in two cases. Microdissection-based mutational analysis revealed that these mesenchymal cells also harbor the same β-catenin gene mutations as those of epithelial cells, suggesting their tumorous nature. Thus, at least a subset of adamantinomatous craniopharyngioma is considered to be biphasic.",
author = "Shigeki Sekine and Tatsuhiro Shibata and Akiko Kokubu and Yukio Morishita and Masayuki Noguchi and Yukihiro Nakanishi and Michiie Sakamoto and Setsuo Hirohashi",
year = "2002",
month = "12",
day = "1",
language = "English",
volume = "161",
pages = "1997--2001",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations

AU - Sekine, Shigeki

AU - Shibata, Tatsuhiro

AU - Kokubu, Akiko

AU - Morishita, Yukio

AU - Noguchi, Masayuki

AU - Nakanishi, Yukihiro

AU - Sakamoto, Michiie

AU - Hirohashi, Setsuo

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Craniopharyngioma is a rare tumor occurring in the sellar region comprising 3% of all intracranial tumors. To elucidate the contribution of β-catenin gene mutation to tumorigenesis, we examined genetic alterations and expression of β-catenin in 10 cases of adamantinomatous and 6 cases of papillary craniopharyngiomas. β-Catenin gene mutations were found in all of the adamantinomatous and none of the papillary craniopharyngiomas. Immunohistochemically, all cases of adamantinomatous craniopharyngioma showed cytoplasmic and nuclear expression of β-catenin. In contrast, papillary craniopharyngiomas showed exclusively membranous expression. The results suggest that adamantinomatous- and papillary-type craniopharyngiomas are not only clinicopathologically, but also genetically, distinctive variants. Mutation of the β-catenin gene therefore seems to play an important role in the tumorigenesis of adamantinomatous craniopharyngioma. Among the adamantinomatous-type tumors, β-catenin-positive mesenchymal cells were observed in two cases. Microdissection-based mutational analysis revealed that these mesenchymal cells also harbor the same β-catenin gene mutations as those of epithelial cells, suggesting their tumorous nature. Thus, at least a subset of adamantinomatous craniopharyngioma is considered to be biphasic.

AB - Craniopharyngioma is a rare tumor occurring in the sellar region comprising 3% of all intracranial tumors. To elucidate the contribution of β-catenin gene mutation to tumorigenesis, we examined genetic alterations and expression of β-catenin in 10 cases of adamantinomatous and 6 cases of papillary craniopharyngiomas. β-Catenin gene mutations were found in all of the adamantinomatous and none of the papillary craniopharyngiomas. Immunohistochemically, all cases of adamantinomatous craniopharyngioma showed cytoplasmic and nuclear expression of β-catenin. In contrast, papillary craniopharyngiomas showed exclusively membranous expression. The results suggest that adamantinomatous- and papillary-type craniopharyngiomas are not only clinicopathologically, but also genetically, distinctive variants. Mutation of the β-catenin gene therefore seems to play an important role in the tumorigenesis of adamantinomatous craniopharyngioma. Among the adamantinomatous-type tumors, β-catenin-positive mesenchymal cells were observed in two cases. Microdissection-based mutational analysis revealed that these mesenchymal cells also harbor the same β-catenin gene mutations as those of epithelial cells, suggesting their tumorous nature. Thus, at least a subset of adamantinomatous craniopharyngioma is considered to be biphasic.

UR - http://www.scopus.com/inward/record.url?scp=0036898018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036898018&partnerID=8YFLogxK

M3 - Article

C2 - 12466115

AN - SCOPUS:0036898018

VL - 161

SP - 1997

EP - 2001

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 6

ER -