Creation of a cell-based separation microdevice using human renal proximal tubule epithelial cells

Xiaofang Gao, Kazuma Mawatari, Yutaka Kazoe, Yo Tanaka, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we report a cell-based separation microdevice using human renal proximal tubule epithelial cells. Near organ-level of separation efficiency and selectivity including reabsorption and clearance by renal tubule cells was demonstrated on chip. In addition, cell performance was directly measured under different operating parameters (flow rate and feeding concentration) in order to optimize the cell separating capability. This cell-base separation microdevice also referred to as bioartificial renal tubule on chip has the potential for drug screening and portable medical care device for kidney failure [1].

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages602-604
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Externally publishedYes
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

Keywords

  • Bioartificial renal tubule
  • Cell-based separation
  • Clearance
  • Reabsorption
  • Renal tubule cell

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Gao, X., Mawatari, K., Kazoe, Y., Tanaka, Y., & Kitamori, T. (2012). Creation of a cell-based separation microdevice using human renal proximal tubule epithelial cells. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 602-604). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.