Creation of pure nanodrugs and their anticancer properties

Hitoshi Kasai, Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Koichi Baba, Hidetoshi Oikawa, Hachiro Nakanishi, Masahiro Okada, Mitsuru Shoji, Minoru Ueda, Hiroshi Imahori, Mitsuru Hashida

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.

Original languageEnglish
Pages (from-to)10315-10318
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number41
DOIs
Publication statusPublished - 2012 Oct 8

Fingerprint

irinotecan
Nanoparticles
Camptothecin
Cell proliferation
Dispersions
Cells
Derivatives
Water
Pharmaceutical Preparations

Keywords

  • cancer
  • colloids
  • drug delivery
  • drug design
  • nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Kasai, H., Murakami, T., Ikuta, Y., Koseki, Y., Baba, K., Oikawa, H., ... Hashida, M. (2012). Creation of pure nanodrugs and their anticancer properties. Angewandte Chemie - International Edition, 51(41), 10315-10318. https://doi.org/10.1002/anie.201204596

Creation of pure nanodrugs and their anticancer properties. / Kasai, Hitoshi; Murakami, Tatsuya; Ikuta, Yoshikazu; Koseki, Yoshitaka; Baba, Koichi; Oikawa, Hidetoshi; Nakanishi, Hachiro; Okada, Masahiro; Shoji, Mitsuru; Ueda, Minoru; Imahori, Hiroshi; Hashida, Mitsuru.

In: Angewandte Chemie - International Edition, Vol. 51, No. 41, 08.10.2012, p. 10315-10318.

Research output: Contribution to journalArticle

Kasai, H, Murakami, T, Ikuta, Y, Koseki, Y, Baba, K, Oikawa, H, Nakanishi, H, Okada, M, Shoji, M, Ueda, M, Imahori, H & Hashida, M 2012, 'Creation of pure nanodrugs and their anticancer properties', Angewandte Chemie - International Edition, vol. 51, no. 41, pp. 10315-10318. https://doi.org/10.1002/anie.201204596
Kasai H, Murakami T, Ikuta Y, Koseki Y, Baba K, Oikawa H et al. Creation of pure nanodrugs and their anticancer properties. Angewandte Chemie - International Edition. 2012 Oct 8;51(41):10315-10318. https://doi.org/10.1002/anie.201204596
Kasai, Hitoshi ; Murakami, Tatsuya ; Ikuta, Yoshikazu ; Koseki, Yoshitaka ; Baba, Koichi ; Oikawa, Hidetoshi ; Nakanishi, Hachiro ; Okada, Masahiro ; Shoji, Mitsuru ; Ueda, Minoru ; Imahori, Hiroshi ; Hashida, Mitsuru. / Creation of pure nanodrugs and their anticancer properties. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 41. pp. 10315-10318.
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