Cribriform-morular variant of papillary thyroid carcinoma: Ultrastructural study and somatic/germline mutation analysis of the APC gene

Kaori Kameyama, Makio Mukai, Hiroshi Takami, Koichi Ito

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cribriform-morular variant of papillary carcinoma is a distinctive histological variant of thyroid cancer, characterized by intermingled cribriform, follicular, papillary, trabecular, and morular architecture. These tumors are known to be associated with familial adenomatous polyposis (FAP), but are also encountered in non-FAP patients. The authors report on ultrastructural and genetic studies of 3 patients with this type of carcinoma-associated FAP. There were numerous microfilaments approximately 100 nm long at the nuclear clearing area of the morular regions. Two of the 3 patients showed germline APC mutations, and 1 had so somatic APC mutation. Both mutations were in previously unreported regions. The study provides new information for understanding the development of this rare tumor.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalUltrastructural Pathology
Volume28
Issue number2
DOIs
Publication statusPublished - 2004 Mar 1

Keywords

  • APC gene
  • Cribriform-morular variant
  • Familial adenomatous polyposis
  • Nuclear clearing
  • Papillary carcinoma
  • Thyroid cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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