Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells

Takeshi Shimaoka, Ken Ichiro Seino, Noriaki Kume, Manabu Minami, Chiyoko Nishime, Makoto Suematsu, Toru Kita, Masaru Taniguchi, Kouji Matsushima, Shin Yonehara

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Abstract

The transmembrane chemokine CXCL 16 (CXCL16), which is the same molecule as the scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX), has been shown to mediate chemotaxis and adhesion of CXC chemokine receptor 6-expressing cells such as NKT and activated Th1 cells. We generated SR-PSOX/CXCL16-deficient mice and examined the role of this chemokine in vivo. The mutant mice showed a reduced number of liver NKT cells, and decreased production of IFN-γ and IL-4 by administration of α- galactosylceramide (αGalCer). Of note, the αGalCer-induced production of IFN-γ was more severely impaired than the production of IL-4 in SR-PSOX-deficient mice. In this context, SR-PSOX-deficient mice showed impaired sensitivity to αGalCer-induced anti-tumor effect mediated by IFN-γ from NKT cells. NKT cells from wild-type mice showed impaired production of IFN-γ, but not IL-4, after their culture with αGalCer and APCs from mutant mice. Moreover, Propionibacterium acnes-induced in vivo Th1 responses were severely impaired in SR-PSOX-deficient as well as NKT KO mice. Taken together, SR-PSOX/CXCL16 plays an important role in not only the production of IFN-γ by NKT cells, but also promotion of Th1-inclined immune responses mediated by NKT cells.

Original languageEnglish
Pages (from-to)8172-8179
Number of pages8
JournalJournal of Immunology
Volume179
Issue number12
Publication statusPublished - 2007 Dec 15

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CXC Chemokines
Natural Killer T-Cells
Galactosylceramides
Ligands
Interleukin-4
Chemokines
CXCR Receptors
Scavenger Receptors
Propionibacterium acnes
Th1 Cells
Phosphatidylserines
Chemotaxis
Lipoproteins
Liver

ASJC Scopus subject areas

  • Immunology

Cite this

Shimaoka, T., Seino, K. I., Kume, N., Minami, M., Nishime, C., Suematsu, M., ... Yonehara, S. (2007). Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. Journal of Immunology, 179(12), 8172-8179.

Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. / Shimaoka, Takeshi; Seino, Ken Ichiro; Kume, Noriaki; Minami, Manabu; Nishime, Chiyoko; Suematsu, Makoto; Kita, Toru; Taniguchi, Masaru; Matsushima, Kouji; Yonehara, Shin.

In: Journal of Immunology, Vol. 179, No. 12, 15.12.2007, p. 8172-8179.

Research output: Contribution to journalArticle

Shimaoka, T, Seino, KI, Kume, N, Minami, M, Nishime, C, Suematsu, M, Kita, T, Taniguchi, M, Matsushima, K & Yonehara, S 2007, 'Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells', Journal of Immunology, vol. 179, no. 12, pp. 8172-8179.
Shimaoka T, Seino KI, Kume N, Minami M, Nishime C, Suematsu M et al. Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. Journal of Immunology. 2007 Dec 15;179(12):8172-8179.
Shimaoka, Takeshi ; Seino, Ken Ichiro ; Kume, Noriaki ; Minami, Manabu ; Nishime, Chiyoko ; Suematsu, Makoto ; Kita, Toru ; Taniguchi, Masaru ; Matsushima, Kouji ; Yonehara, Shin. / Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. In: Journal of Immunology. 2007 ; Vol. 179, No. 12. pp. 8172-8179.
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AU - Nishime, Chiyoko

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