Cross-sectional study of pulmonary function in cadmium alloy workers

H. Sakurai, K. Omae, T. Toyama, T. Higashi, T. Nakadate

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Two groups of cadmium workers (7 and 9 men) and a group of reference workers (122 men) were studied for the purpose of determining the pulmonary effects of cadmium. Indices of pulmonary function, based on the forced expiratory flow volume curve and respiratory impedance, were measured for all the groups, and indicators of cadmium exposure and effects on renal tubular reabsorption functions were also measured in the two groups of cadmium workers. The mean blood and urinary levels of cadmium were 2.08 μg/100 ml (185.06 nmol/l) and 32.6 μg/l (290.04 nmol/l), respectively, and the level of inhalation exposure was estimated at about 1 mg/m3 as the 8-h average concentration for about 5 a (a measure of the duration of exposure) in the high-exposure group. The percentage of the predicted function values of the highly-exposed workers showed significant deterioration for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1.0)), peak expiratory flow, maximum expiratory flow at 75, 50, and 25% of the FVC, percentage of FEV(1.0) to FVC, and respiratory impedance, whereas those of the slightly-exposed workers were reduced only for FVC and FEV(1.0). A paired comparison between the highly-exposed workers and matched referents disclosed the same results. It was concluded that chronic obstructive pulmonary changes had been induced by cadmium in Japanese workers without a history of acute or subacute cadmium pneumonitis.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalScandinavian Journal of Work, Environment and Health
Volume8
Issue numberSuppl. 1
Publication statusPublished - 1982

Fingerprint

Cadmium alloys
Cadmium
cross-sectional study
cadmium
Cross-Sectional Studies
worker
Vital Capacity
Lung
Forced Expiratory Volume
Electric Impedance
Group
Inhalation Exposure
Matched-Pair Analysis
peak flow
Deterioration
Pneumonia
Blood
blood
exposure

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Geography, Planning and Development
  • Health, Toxicology and Mutagenesis

Cite this

Sakurai, H., Omae, K., Toyama, T., Higashi, T., & Nakadate, T. (1982). Cross-sectional study of pulmonary function in cadmium alloy workers. Scandinavian Journal of Work, Environment and Health, 8(Suppl. 1), 122-130.

Cross-sectional study of pulmonary function in cadmium alloy workers. / Sakurai, H.; Omae, K.; Toyama, T.; Higashi, T.; Nakadate, T.

In: Scandinavian Journal of Work, Environment and Health, Vol. 8, No. Suppl. 1, 1982, p. 122-130.

Research output: Contribution to journalArticle

Sakurai, H, Omae, K, Toyama, T, Higashi, T & Nakadate, T 1982, 'Cross-sectional study of pulmonary function in cadmium alloy workers', Scandinavian Journal of Work, Environment and Health, vol. 8, no. Suppl. 1, pp. 122-130.
Sakurai H, Omae K, Toyama T, Higashi T, Nakadate T. Cross-sectional study of pulmonary function in cadmium alloy workers. Scandinavian Journal of Work, Environment and Health. 1982;8(Suppl. 1):122-130.
Sakurai, H. ; Omae, K. ; Toyama, T. ; Higashi, T. ; Nakadate, T. / Cross-sectional study of pulmonary function in cadmium alloy workers. In: Scandinavian Journal of Work, Environment and Health. 1982 ; Vol. 8, No. Suppl. 1. pp. 122-130.
@article{c92920506024440989940cf933ce3ba3,
title = "Cross-sectional study of pulmonary function in cadmium alloy workers",
abstract = "Two groups of cadmium workers (7 and 9 men) and a group of reference workers (122 men) were studied for the purpose of determining the pulmonary effects of cadmium. Indices of pulmonary function, based on the forced expiratory flow volume curve and respiratory impedance, were measured for all the groups, and indicators of cadmium exposure and effects on renal tubular reabsorption functions were also measured in the two groups of cadmium workers. The mean blood and urinary levels of cadmium were 2.08 μg/100 ml (185.06 nmol/l) and 32.6 μg/l (290.04 nmol/l), respectively, and the level of inhalation exposure was estimated at about 1 mg/m3 as the 8-h average concentration for about 5 a (a measure of the duration of exposure) in the high-exposure group. The percentage of the predicted function values of the highly-exposed workers showed significant deterioration for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1.0)), peak expiratory flow, maximum expiratory flow at 75, 50, and 25{\%} of the FVC, percentage of FEV(1.0) to FVC, and respiratory impedance, whereas those of the slightly-exposed workers were reduced only for FVC and FEV(1.0). A paired comparison between the highly-exposed workers and matched referents disclosed the same results. It was concluded that chronic obstructive pulmonary changes had been induced by cadmium in Japanese workers without a history of acute or subacute cadmium pneumonitis.",
author = "H. Sakurai and K. Omae and T. Toyama and T. Higashi and T. Nakadate",
year = "1982",
language = "English",
volume = "8",
pages = "122--130",
journal = "Scandinavian Journal of Work, Environment and Health",
issn = "0355-3140",
publisher = "Finnish Institute of Occupational Health",
number = "Suppl. 1",

}

TY - JOUR

T1 - Cross-sectional study of pulmonary function in cadmium alloy workers

AU - Sakurai, H.

AU - Omae, K.

AU - Toyama, T.

AU - Higashi, T.

AU - Nakadate, T.

PY - 1982

Y1 - 1982

N2 - Two groups of cadmium workers (7 and 9 men) and a group of reference workers (122 men) were studied for the purpose of determining the pulmonary effects of cadmium. Indices of pulmonary function, based on the forced expiratory flow volume curve and respiratory impedance, were measured for all the groups, and indicators of cadmium exposure and effects on renal tubular reabsorption functions were also measured in the two groups of cadmium workers. The mean blood and urinary levels of cadmium were 2.08 μg/100 ml (185.06 nmol/l) and 32.6 μg/l (290.04 nmol/l), respectively, and the level of inhalation exposure was estimated at about 1 mg/m3 as the 8-h average concentration for about 5 a (a measure of the duration of exposure) in the high-exposure group. The percentage of the predicted function values of the highly-exposed workers showed significant deterioration for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1.0)), peak expiratory flow, maximum expiratory flow at 75, 50, and 25% of the FVC, percentage of FEV(1.0) to FVC, and respiratory impedance, whereas those of the slightly-exposed workers were reduced only for FVC and FEV(1.0). A paired comparison between the highly-exposed workers and matched referents disclosed the same results. It was concluded that chronic obstructive pulmonary changes had been induced by cadmium in Japanese workers without a history of acute or subacute cadmium pneumonitis.

AB - Two groups of cadmium workers (7 and 9 men) and a group of reference workers (122 men) were studied for the purpose of determining the pulmonary effects of cadmium. Indices of pulmonary function, based on the forced expiratory flow volume curve and respiratory impedance, were measured for all the groups, and indicators of cadmium exposure and effects on renal tubular reabsorption functions were also measured in the two groups of cadmium workers. The mean blood and urinary levels of cadmium were 2.08 μg/100 ml (185.06 nmol/l) and 32.6 μg/l (290.04 nmol/l), respectively, and the level of inhalation exposure was estimated at about 1 mg/m3 as the 8-h average concentration for about 5 a (a measure of the duration of exposure) in the high-exposure group. The percentage of the predicted function values of the highly-exposed workers showed significant deterioration for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1.0)), peak expiratory flow, maximum expiratory flow at 75, 50, and 25% of the FVC, percentage of FEV(1.0) to FVC, and respiratory impedance, whereas those of the slightly-exposed workers were reduced only for FVC and FEV(1.0). A paired comparison between the highly-exposed workers and matched referents disclosed the same results. It was concluded that chronic obstructive pulmonary changes had been induced by cadmium in Japanese workers without a history of acute or subacute cadmium pneumonitis.

UR - http://www.scopus.com/inward/record.url?scp=0020327075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020327075&partnerID=8YFLogxK

M3 - Article

C2 - 6980459

AN - SCOPUS:0020327075

VL - 8

SP - 122

EP - 130

JO - Scandinavian Journal of Work, Environment and Health

JF - Scandinavian Journal of Work, Environment and Health

SN - 0355-3140

IS - Suppl. 1

ER -