Cryptogenic fulminant hepatic failure in infancy: Report of 2 cases with unique vascular obstructive changes in native livers

Naoki Shimojima, Rie Shibata, Ken Hoshino, Shigeyuki Kawachi, Minoru Tanabe, Go Wakabayashi, Motohide Shimazu, Michiie Sakamoto, Yasuhide Morikawa, Masaki Kitajima

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4 Citations (Scopus)

Abstract

Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalLiver Transplantation
Volume12
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

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    Shimojima, N., Shibata, R., Hoshino, K., Kawachi, S., Tanabe, M., Wakabayashi, G., Shimazu, M., Sakamoto, M., Morikawa, Y., & Kitajima, M. (2006). Cryptogenic fulminant hepatic failure in infancy: Report of 2 cases with unique vascular obstructive changes in native livers. Liver Transplantation, 12(9), 1418-1422. https://doi.org/10.1002/lt.20850