Cryptogenic fulminant hepatic failure in infancy: Report of 2 cases with unique vascular obstructive changes in native livers

Naoki Shimojima, Rie Shibata, Ken Hoshino, Shigeyuki Kawachi, Minoru Tanabe, Go Wakabayashi, Motohide Shimazu, Michiie Sakamoto, Yasuhide Morikawa, Masaki Kitajima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalLiver Transplantation
Volume12
Issue number9
DOIs
Publication statusPublished - 2006 Sep

Fingerprint

Acute Liver Failure
Blood Vessels
Liver
Hepatic Veno-Occlusive Disease
Portal Vein
Hepatocytes
Veins
Transplantation

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Shimojima, N., Shibata, R., Hoshino, K., Kawachi, S., Tanabe, M., Wakabayashi, G., ... Kitajima, M. (2006). Cryptogenic fulminant hepatic failure in infancy: Report of 2 cases with unique vascular obstructive changes in native livers. Liver Transplantation, 12(9), 1418-1422. https://doi.org/10.1002/lt.20850

Cryptogenic fulminant hepatic failure in infancy : Report of 2 cases with unique vascular obstructive changes in native livers. / Shimojima, Naoki; Shibata, Rie; Hoshino, Ken; Kawachi, Shigeyuki; Tanabe, Minoru; Wakabayashi, Go; Shimazu, Motohide; Sakamoto, Michiie; Morikawa, Yasuhide; Kitajima, Masaki.

In: Liver Transplantation, Vol. 12, No. 9, 09.2006, p. 1418-1422.

Research output: Contribution to journalArticle

Shimojima, N, Shibata, R, Hoshino, K, Kawachi, S, Tanabe, M, Wakabayashi, G, Shimazu, M, Sakamoto, M, Morikawa, Y & Kitajima, M 2006, 'Cryptogenic fulminant hepatic failure in infancy: Report of 2 cases with unique vascular obstructive changes in native livers', Liver Transplantation, vol. 12, no. 9, pp. 1418-1422. https://doi.org/10.1002/lt.20850
Shimojima, Naoki ; Shibata, Rie ; Hoshino, Ken ; Kawachi, Shigeyuki ; Tanabe, Minoru ; Wakabayashi, Go ; Shimazu, Motohide ; Sakamoto, Michiie ; Morikawa, Yasuhide ; Kitajima, Masaki. / Cryptogenic fulminant hepatic failure in infancy : Report of 2 cases with unique vascular obstructive changes in native livers. In: Liver Transplantation. 2006 ; Vol. 12, No. 9. pp. 1418-1422.
@article{af04b97ec2f4402185d98ad011b72bbc,
title = "Cryptogenic fulminant hepatic failure in infancy: Report of 2 cases with unique vascular obstructive changes in native livers",
abstract = "Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.",
author = "Naoki Shimojima and Rie Shibata and Ken Hoshino and Shigeyuki Kawachi and Minoru Tanabe and Go Wakabayashi and Motohide Shimazu and Michiie Sakamoto and Yasuhide Morikawa and Masaki Kitajima",
year = "2006",
month = "9",
doi = "10.1002/lt.20850",
language = "English",
volume = "12",
pages = "1418--1422",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

TY - JOUR

T1 - Cryptogenic fulminant hepatic failure in infancy

T2 - Report of 2 cases with unique vascular obstructive changes in native livers

AU - Shimojima, Naoki

AU - Shibata, Rie

AU - Hoshino, Ken

AU - Kawachi, Shigeyuki

AU - Tanabe, Minoru

AU - Wakabayashi, Go

AU - Shimazu, Motohide

AU - Sakamoto, Michiie

AU - Morikawa, Yasuhide

AU - Kitajima, Masaki

PY - 2006/9

Y1 - 2006/9

N2 - Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.

AB - Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.

UR - http://www.scopus.com/inward/record.url?scp=33748806005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748806005&partnerID=8YFLogxK

U2 - 10.1002/lt.20850

DO - 10.1002/lt.20850

M3 - Article

C2 - 16933237

AN - SCOPUS:33748806005

VL - 12

SP - 1418

EP - 1422

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 9

ER -