TY - JOUR
T1 - Cryptogenic fulminant hepatic failure in infancy
T2 - Report of 2 cases with unique vascular obstructive changes in native livers
AU - Shimojima, Naoki
AU - Shibata, Rie
AU - Hoshino, Ken
AU - Kawachi, Shigeyuki
AU - Tanabe, Minoru
AU - Wakabayashi, Go
AU - Shimazu, Motohide
AU - Sakamoto, Michiie
AU - Morikawa, Yasuhide
AU - Kitajima, Masaki
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/9
Y1 - 2006/9
N2 - Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.
AB - Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.
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U2 - 10.1002/lt.20850
DO - 10.1002/lt.20850
M3 - Article
C2 - 16933237
AN - SCOPUS:33748806005
VL - 12
SP - 1418
EP - 1422
JO - Liver Transplantation
JF - Liver Transplantation
SN - 1527-6465
IS - 9
ER -