Abstract
Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.
| Original language | English |
|---|---|
| Pages (from-to) | 1418-1422 |
| Number of pages | 5 |
| Journal | Liver Transplantation |
| Volume | 12 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2006 Sep |
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ASJC Scopus subject areas
- Surgery
- Transplantation
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Cryptogenic fulminant hepatic failure in infancy : Report of 2 cases with unique vascular obstructive changes in native livers. / Shimojima, Naoki; Shibata, Rie; Hoshino, Ken; Kawachi, Shigeyuki; Tanabe, Minoru; Wakabayashi, Go; Shimazu, Motohide; Sakamoto, Michiie; Morikawa, Yasuhide; Kitajima, Masaki.
In: Liver Transplantation, Vol. 12, No. 9, 09.2006, p. 1418-1422.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cryptogenic fulminant hepatic failure in infancy
T2 - Report of 2 cases with unique vascular obstructive changes in native livers
AU - Shimojima, Naoki
AU - Shibata, Rie
AU - Hoshino, Ken
AU - Kawachi, Shigeyuki
AU - Tanabe, Minoru
AU - Wakabayashi, Go
AU - Shimazu, Motohide
AU - Sakamoto, Michiie
AU - Morikawa, Yasuhide
AU - Kitajima, Masaki
PY - 2006/9
Y1 - 2006/9
N2 - Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.
AB - Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.
UR - http://www.scopus.com/inward/record.url?scp=33748806005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748806005&partnerID=8YFLogxK
U2 - 10.1002/lt.20850
DO - 10.1002/lt.20850
M3 - Article
C2 - 16933237
AN - SCOPUS:33748806005
VL - 12
SP - 1418
EP - 1422
JO - Liver Transplantation
JF - Liver Transplantation
SN - 1527-6465
IS - 9
ER -