Crystal structure of (±)-(1SR,5SR,6SR,7SR,10SR,-11 SR,13SR)-13-benzyloxy-7-methoxymethoxy-11,15,18,18-tetramethyl-3-oxo-2,4-dioxatetra-cyclo[12.3.1.01,5.06,11]octadeca-14,16-dien-10-yl benzoate

Takeshi Oishi, Keisuke Fukaya, Yu Yamaguchi, Tomoya Sugai, Ami Watanabe, Takaaki Sato, Noritaka Chida, H. Ishida

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the title compound, C36H42O8, the dioxolane ring adopts a twist conformation; the two adjacent C atoms deviate alternately from the mean plane of other atoms by - 0.287 (5) and 0.174 (5) Å. The cyclohexane, cyclohexadiene and central cyclooctane rings show chair, half-chair and boat-chair forms, respectively. As a result of the strained ring system, the tetrasubsituted olefin in the cyclohexadiene is skewed from an ideal planar structure. In the crystal, C - H⋯O hydrogen bonds connect the molecules into a sheet parallel to (100). The sheets are further linked by other weak C - H⋯O and C - H⋯π interactions, forming a three-dimensional network.

Original languageEnglish
Pages (from-to)490-493
Number of pages4
JournalActa Crystallographica Section E: Structure Reports Online
Volume71
Issue number5
DOIs
Publication statusPublished - 2015 May 1

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Keywords

  • C - H⋯π interactions
  • Crystal structure
  • Hydrogen bonding
  • Hydrogen bonds
  • Paclitaxel
  • Taxane skeleton

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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