Abstract
Vitiligo, which is histologically characterized by the absence of epidermal melanocytes, is manifested as irregular depigmented macules of the skin that can vary in size from minute to large in any area of the body. Patients with vitiligo are mainly treated with psoralens and ultraviolet A (PUVA) or corticosteroids, singly or in combination, but the results of these therapies are occassionally disappointing and, for some cases, ineffective. Thus, in the search for better vitiligo therapies, clinical trials have been conducted using autografts, such as a punch graft, minigrafts, or an epidermal graft, and while these grafts have induced skin repigmentation, the appearance is often uneven and spotty and flawed by unsightly scarring. To avoid scarring, we have tried another approach using cultured autologus epithelia grafting, first reported by Todd in 1989, in 5 patients with vitiligo and have achieved considerable repigmentation, ranging from 30 to 95% of the graft. The reason for this pigmentation inconsistency is thought due to the state of the vitiligo, which in some patients was still active. We thus have concluded that cultured autologus epithelia transplantation may hold promise as a treatment method for patients with inactive vitiligo.
| Original language | English |
|---|---|
| Pages (from-to) | 161-169 |
| Number of pages | 9 |
| Journal | Japanese Journal of Plastic and Reconstructive Surgery |
| Volume | 39 |
| Issue number | 2 |
| Publication status | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Cultured autologus epithelia grafting for treating vitiligo : Results in 5 cases. / Ohshima, H.; Kumagai, N.; Matsuzaki, K.; Fukushi, S.; Tanabe, M.; Ishida, H.; Uchikoshi, T.
In: Japanese Journal of Plastic and Reconstructive Surgery, Vol. 39, No. 2, 1996, p. 161-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cultured autologus epithelia grafting for treating vitiligo
T2 - Results in 5 cases
AU - Ohshima, H.
AU - Kumagai, N.
AU - Matsuzaki, K.
AU - Fukushi, S.
AU - Tanabe, M.
AU - Ishida, H.
AU - Uchikoshi, T.
PY - 1996
Y1 - 1996
N2 - Vitiligo, which is histologically characterized by the absence of epidermal melanocytes, is manifested as irregular depigmented macules of the skin that can vary in size from minute to large in any area of the body. Patients with vitiligo are mainly treated with psoralens and ultraviolet A (PUVA) or corticosteroids, singly or in combination, but the results of these therapies are occassionally disappointing and, for some cases, ineffective. Thus, in the search for better vitiligo therapies, clinical trials have been conducted using autografts, such as a punch graft, minigrafts, or an epidermal graft, and while these grafts have induced skin repigmentation, the appearance is often uneven and spotty and flawed by unsightly scarring. To avoid scarring, we have tried another approach using cultured autologus epithelia grafting, first reported by Todd in 1989, in 5 patients with vitiligo and have achieved considerable repigmentation, ranging from 30 to 95% of the graft. The reason for this pigmentation inconsistency is thought due to the state of the vitiligo, which in some patients was still active. We thus have concluded that cultured autologus epithelia transplantation may hold promise as a treatment method for patients with inactive vitiligo.
AB - Vitiligo, which is histologically characterized by the absence of epidermal melanocytes, is manifested as irregular depigmented macules of the skin that can vary in size from minute to large in any area of the body. Patients with vitiligo are mainly treated with psoralens and ultraviolet A (PUVA) or corticosteroids, singly or in combination, but the results of these therapies are occassionally disappointing and, for some cases, ineffective. Thus, in the search for better vitiligo therapies, clinical trials have been conducted using autografts, such as a punch graft, minigrafts, or an epidermal graft, and while these grafts have induced skin repigmentation, the appearance is often uneven and spotty and flawed by unsightly scarring. To avoid scarring, we have tried another approach using cultured autologus epithelia grafting, first reported by Todd in 1989, in 5 patients with vitiligo and have achieved considerable repigmentation, ranging from 30 to 95% of the graft. The reason for this pigmentation inconsistency is thought due to the state of the vitiligo, which in some patients was still active. We thus have concluded that cultured autologus epithelia transplantation may hold promise as a treatment method for patients with inactive vitiligo.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029927856&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029927856
VL - 39
SP - 161
EP - 169
JO - Japanese Journal of Plastic Surgery
JF - Japanese Journal of Plastic Surgery
SN - 0021-5228
IS - 2
ER -