Current Aspects of Pediatric Pharmacokinetics and Pharmacodynamics of Antimicrobials in Japan: Importance of the Promotion of Population PK/PD Analysis

Kensuke Shoji, Jumpei Saito, Hidefumi Nakamura, Kazuaki Matsumoto, Kazutaka Oda, Yoshio Takesue, Isao Miyairi

Research output: Contribution to journalReview articlepeer-review

Abstract

Pharmacologic knowledge is important for pediatricians conducting feasible pharmacokinetic or pharmacodynamic (PK/PD) studies or applying effective antimicrobial therapies in children. Because of the difficulties in conducting PK/PD studies in children, antimicrobial PK/PD data in children are still limited. To fill in the lack of knowledge, promotion of population PK/PD analysis, which allows us to handle sparse sampling data from individual patients, is important because it is considered a suitable methodology to conduct PK/PD studies in children with limited blood drug concentration data for PK/PD analysis. Population PK/PD analysis is also useful in the clinical setting to provide individualized optimal dosage for each patient with various conditions. Here we summarized the current aspects of pediatric PK/PD studies of antimicrobials in Japan from clinical and research perspectives, specifically focusing on the importance of population PK/PD analysis.

Original languageEnglish
Pages (from-to)E418-E423
JournalPediatric Infectious Disease Journal
Volume41
Issue number10
DOIs
Publication statusPublished - 2022 Oct 1

Keywords

  • pharmacodynamics
  • pharmacokinetics
  • population PK/PD

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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