Current clinical trials using new targeted therapies for myeloid leukemia and the research trends

J. Ishizawa, Hideyuki Saya

Research output: Contribution to journalReview article

Abstract

Great progress on insight into genetic aberrations of myeloid leukemia via gene expression profiling has led to better understanding of the pathobiology of this heterogeneous disorder. It enabled the development of specific treatment modalities targeted to underlying oncogenic abnormalities, with well established examples of all-trans retinoic acid for the treatment of acute promyelocytic leukemia and imatinib for chronic myeloid leukemia. However, these strategies have not been completely developed yet in that most of brand new targeted therapies have been somewhat far from achieving cure of leukemia and that many problems with regards to drug resistance and recurrence from minimal residual disease remain to be solved. On the other hand, concept of cancer(leukemic) stem cell and its niche has been shedding new light on oncological field these days. This review summarizes the current clinical trials using new targeted therapies and research trends on myeloid leukemia.

Original languageEnglish
Pages (from-to)1932-1937
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume67
Issue number10
Publication statusPublished - 2009 Oct

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ASJC Scopus subject areas

  • Medicine(all)

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