Current consensus on the diagnosis and treatment of H. pylori-associated gastroduodenal disease

Hidekazu Suzuki, Tatsuhiro Masaoka, Sachiko Nomura, Yoshinori Hoshino, Kumiko Kurabayashi, Yuriko Minegishi, Masayuki Suzuki, Hiromasa Ishii

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) is a spiral shaped bacterium that resides in the stomach mucosa. Isolation of H. pylori from the stomach mucosa changed the erstwhile widely held belief that the stomach contains no bacteria and is actually sterile. Once H. pylori is safely ensconced in the mucus, it is able to neutralize the acid in the stomach by elaborating an enzyme called urease. Urease converts urea, of which there is an abundant supply in the stomach (derived from saliva and the gastric juice), into bicarbonate and ammonia, which are strong bases. These bases form a cloud of acid-neutralizing chemicals in the vicinity of the organisms, protecting them from the acid in the stomach. This urea hydrolysis reaction is utilized for the diagnosis of H. pylori infection in the urea breath test (UBT) and the rapid urease test (RUT). In Japan, both invasive tests, such as bacterial culture, histopathology and RUT, and non-invasive tests such as UBT and serology are conducted for the diagnosis of H. pylori infection. For confirming the results of eradication therapy, UBT is considered to be the most sensitive and specific. In order to treat H. pylori infection, a new one-week triple therapy regimen (lansoprazole or omeprazole + amoxicillin + clarithromycin) has been approved for use in patients with peptic ulcer disease in Japan. As for H. pylori eradication in the case of other diseases in which the bacterium has been implicated (e.g., chronic atrophic gastritis, gastric MALT lymphoma, gastric cancer, non-ulcer dyspepsia, chronic urticaria, idiopathic thrombocytopenic purpura (ITP)), further basic and clinical investigation is required.

Original languageEnglish
Pages (from-to)163-173
Number of pages11
JournalKeio Journal of Medicine
Volume52
Issue number3
DOIs
Publication statusPublished - 2003 Sep

Keywords

  • Apoptosis
  • Rapid urease test
  • Triple therapy
  • Urea breath test
  • Urease

ASJC Scopus subject areas

  • Medicine(all)

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    Suzuki, H., Masaoka, T., Nomura, S., Hoshino, Y., Kurabayashi, K., Minegishi, Y., Suzuki, M., & Ishii, H. (2003). Current consensus on the diagnosis and treatment of H. pylori-associated gastroduodenal disease. Keio Journal of Medicine, 52(3), 163-173. https://doi.org/10.2302/kjm.52.163