Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPase

Atsuhiro Ichihara, Kenichiro Kinouchi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The (pro)renin receptor (P)RR is a receptor for renin and prorenin, not only allowing local production of angiotensin I from angiotensinogen, but also inducing intracellular signaling. Intriguingly, (P)RR is also called ATP6AP2 because a (P)RR fragment was demonstrated to be associated with vacuolar-type H+-ATPase (V-ATPase), which is of importance for the maintenance of intracellular pH. Recent studies implicate that deletion of (P)RR results in the dysfunction of V-ATPase, suggesting that the (P)RR is essential for its role as a proton pump. Furthermore, the novel function of (P)RR as an adaptor protein between the Wnt receptor complex and the V-ATPase was discovered. Thus, (P)RR is a multi-functional molecule with functions beyond renin and prorenin. This review focuses on the current knowledge and issues of (P)RR and V-ATPase.

Original languageEnglish
Pages (from-to)638-640
Number of pages3
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume12
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1

Keywords

  • (P)RR
  • RAS
  • V-ATPase

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

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