Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair

Human pluripotent stem cell (hPSC)-based therapies can be delivered as injection, as sheets of interconnected cells, or after suspending the cells in a scaffold of material that is designed to mimic the native extracellular matrix. The methods used to deliver cell therapy are being reviewed. The cell patch can be modified for the codelivery of peptides that may promote the survival and activate endogenous repair mechanisms. The scaffold-based approaches are currently suitable for applications that require thicker grafts, because the scaffold may be more readily vascularized by the host circulation. The effectiveness of hPSC therapy for myocardial repair can be enhanced by techniques that control inflammation, limit apoptosis, and improve vascular growth.