Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair

Jun Fujita, Keiichi Fukuda, Leslie W. Miller, Jianyi Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human pluripotent stem cell (hPSC)-based therapies can be delivered as injection, as sheets of interconnected cells, or after suspending the cells in a scaffold of material that is designed to mimic the native extracellular matrix. The methods used to deliver cell therapy are being reviewed. The cell patch can be modified for the codelivery of peptides that may promote the survival and activate endogenous repair mechanisms. The scaffold-based approaches are currently suitable for applications that require thicker grafts, because the scaffold may be more readily vascularized by the host circulation. The effectiveness of hPSC therapy for myocardial repair can be enhanced by techniques that control inflammation, limit apoptosis, and improve vascular growth.

Original languageEnglish
Title of host publicationStem Cell and Gene Therapy for Cardiovascular Disease
PublisherElsevier Science Ltd.
Pages297-308
Number of pages12
ISBN (Electronic)9780128018637
ISBN (Print)9780128018880
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Extracellular Matrix
Blood Vessels
Apoptosis
Inflammation
Transplants
Peptides
Injections
Survival
Growth

Keywords

  • Heart
  • Infarction
  • Scaffold
  • Stem cell
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fujita, J., Fukuda, K., Miller, L. W., & Zhang, J. (2015). Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair. In Stem Cell and Gene Therapy for Cardiovascular Disease (pp. 297-308). Elsevier Science Ltd.. https://doi.org/10.1016/B978-0-12-801888-0.00024-2

Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair. / Fujita, Jun; Fukuda, Keiichi; Miller, Leslie W.; Zhang, Jianyi.

Stem Cell and Gene Therapy for Cardiovascular Disease. Elsevier Science Ltd., 2015. p. 297-308.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fujita, J, Fukuda, K, Miller, LW & Zhang, J 2015, Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair. in Stem Cell and Gene Therapy for Cardiovascular Disease. Elsevier Science Ltd., pp. 297-308. https://doi.org/10.1016/B978-0-12-801888-0.00024-2
Fujita J, Fukuda K, Miller LW, Zhang J. Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair. In Stem Cell and Gene Therapy for Cardiovascular Disease. Elsevier Science Ltd. 2015. p. 297-308 https://doi.org/10.1016/B978-0-12-801888-0.00024-2
Fujita, Jun ; Fukuda, Keiichi ; Miller, Leslie W. ; Zhang, Jianyi. / Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair. Stem Cell and Gene Therapy for Cardiovascular Disease. Elsevier Science Ltd., 2015. pp. 297-308
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