Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis

Tetsuya Nakamura; Masakazu Nagahori; Takanori Kanai; Mamoru Watanabe

doi:10.1159/000111486

Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis

Tetsuya Nakamura, Masakazu Nagahori, Takanori Kanai, Mamoru Watanabe

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/or dosage regimens have changed their placements in the medical management of UC. In addition, studies have shown that a number of novel therapeutic agents, designed to target specific mechanisms involved in the inflammatory cascade, have efficacy for the treatment of UC and they will have significant clinical impacts in the near future. A clear understanding of the proven and potential benefits of both the standard and emerging therapies will be required for the optimum individual care of patients with varied clinical presentations.

Original language	English
Pages (from-to)	36-41
Number of pages	6
Journal	Digestion
Volume	77
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1159/000111486
Publication status	Published - 2008 Jan
Externally published	Yes

Keywords

Aminosalicylates
Biologic therapy
Corticosteroids
Immunosuppressants
Ulcerative colitis

ASJC Scopus subject areas

Gastroenterology

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10.1159/000111486

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abstract = "Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/or dosage regimens have changed their placements in the medical management of UC. In addition, studies have shown that a number of novel therapeutic agents, designed to target specific mechanisms involved in the inflammatory cascade, have efficacy for the treatment of UC and they will have significant clinical impacts in the near future. A clear understanding of the proven and potential benefits of both the standard and emerging therapies will be required for the optimum individual care of patients with varied clinical presentations.",

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AU - Kanai, Takanori

AU - Watanabe, Mamoru

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AB - Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/or dosage regimens have changed their placements in the medical management of UC. In addition, studies have shown that a number of novel therapeutic agents, designed to target specific mechanisms involved in the inflammatory cascade, have efficacy for the treatment of UC and they will have significant clinical impacts in the near future. A clear understanding of the proven and potential benefits of both the standard and emerging therapies will be required for the optimum individual care of patients with varied clinical presentations.

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Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis

Abstract

Keywords

ASJC Scopus subject areas

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