Abstract
Severe alcoholic hepatitis (SAH) has a high mortality rate. Ability of Japan Alcoholic Hepatitis Score (JAS) to predict outcome was confirmed by examining the data of 90 patients with AH in 2012: 53 had moderate AH of whom 45 were alive and 8 were dead, while 37 had SAH of whom 21 were alive and 16 were dead. The prevalence of DIC was higher in patients who had died, while TB at 5 days was higher in SAH patients who had died. WBC and PT (INR) at 5 days were higher in moderate AH patients who had died. These results suggest that JAS allows stratification of the risk of death and can help manage patients with AH. Irrespective of severity, the treatment such as steroid should be carried out if WBC, PT (INR) or TB at 5 days were not yet fully recovered.
| Original language | English |
|---|---|
| Pages (from-to) | 171-177 |
| Number of pages | 7 |
| Journal | Acta Hepatologica Japonica |
| Volume | 57 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 Apr 29 |
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Keywords
- Alcoholic hepatitis
- Bilirubin prothrombin time
- Corticosteroids
- Japan Alcoholic Hepatitis Score
ASJC Scopus subject areas
- Hepatology
Cite this
Current status of alcoholic hepatitis in Japan (2012). / Horie, Yoshinori; Ebinuma, Hirotoshi; Kikuchi, Hiromasa; Shiba, Syunsuke; Nakamoto, Nobuhiro; Kanai, Takanori.
In: Acta Hepatologica Japonica, Vol. 57, No. 4, 29.04.2016, p. 171-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Current status of alcoholic hepatitis in Japan (2012)
AU - Horie, Yoshinori
AU - Ebinuma, Hirotoshi
AU - Kikuchi, Hiromasa
AU - Shiba, Syunsuke
AU - Nakamoto, Nobuhiro
AU - Kanai, Takanori
PY - 2016/4/29
Y1 - 2016/4/29
N2 - Severe alcoholic hepatitis (SAH) has a high mortality rate. Ability of Japan Alcoholic Hepatitis Score (JAS) to predict outcome was confirmed by examining the data of 90 patients with AH in 2012: 53 had moderate AH of whom 45 were alive and 8 were dead, while 37 had SAH of whom 21 were alive and 16 were dead. The prevalence of DIC was higher in patients who had died, while TB at 5 days was higher in SAH patients who had died. WBC and PT (INR) at 5 days were higher in moderate AH patients who had died. These results suggest that JAS allows stratification of the risk of death and can help manage patients with AH. Irrespective of severity, the treatment such as steroid should be carried out if WBC, PT (INR) or TB at 5 days were not yet fully recovered.
AB - Severe alcoholic hepatitis (SAH) has a high mortality rate. Ability of Japan Alcoholic Hepatitis Score (JAS) to predict outcome was confirmed by examining the data of 90 patients with AH in 2012: 53 had moderate AH of whom 45 were alive and 8 were dead, while 37 had SAH of whom 21 were alive and 16 were dead. The prevalence of DIC was higher in patients who had died, while TB at 5 days was higher in SAH patients who had died. WBC and PT (INR) at 5 days were higher in moderate AH patients who had died. These results suggest that JAS allows stratification of the risk of death and can help manage patients with AH. Irrespective of severity, the treatment such as steroid should be carried out if WBC, PT (INR) or TB at 5 days were not yet fully recovered.
KW - Alcoholic hepatitis
KW - Bilirubin prothrombin time
KW - Corticosteroids
KW - Japan Alcoholic Hepatitis Score
UR - http://www.scopus.com/inward/record.url?scp=84964808163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964808163&partnerID=8YFLogxK
U2 - 10.2957/kanzo.57.171
DO - 10.2957/kanzo.57.171
M3 - Article
AN - SCOPUS:84964808163
VL - 57
SP - 171
EP - 177
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
SN - 0451-4203
IS - 4
ER -