Current status of alcoholic hepatitis in Japan (2012)

Yoshinori Horie, Hirotoshi Ebinuma, Hiromasa Kikuchi, Syunsuke Shiba, Nobuhiro Nakamoto, Takanori Kanai

Research output: Contribution to journalArticle

Abstract

Severe alcoholic hepatitis (SAH) has a high mortality rate. Ability of Japan Alcoholic Hepatitis Score (JAS) to predict outcome was confirmed by examining the data of 90 patients with AH in 2012: 53 had moderate AH of whom 45 were alive and 8 were dead, while 37 had SAH of whom 21 were alive and 16 were dead. The prevalence of DIC was higher in patients who had died, while TB at 5 days was higher in SAH patients who had died. WBC and PT (INR) at 5 days were higher in moderate AH patients who had died. These results suggest that JAS allows stratification of the risk of death and can help manage patients with AH. Irrespective of severity, the treatment such as steroid should be carried out if WBC, PT (INR) or TB at 5 days were not yet fully recovered.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalActa Hepatologica Japonica
Volume57
Issue number4
DOIs
Publication statusPublished - 2016 Apr 29

Fingerprint

Alcoholic Hepatitis
Japan
International Normalized Ratio
Dacarbazine
Steroids
Mortality

Keywords

  • Alcoholic hepatitis
  • Bilirubin prothrombin time
  • Corticosteroids
  • Japan Alcoholic Hepatitis Score

ASJC Scopus subject areas

  • Hepatology

Cite this

Current status of alcoholic hepatitis in Japan (2012). / Horie, Yoshinori; Ebinuma, Hirotoshi; Kikuchi, Hiromasa; Shiba, Syunsuke; Nakamoto, Nobuhiro; Kanai, Takanori.

In: Acta Hepatologica Japonica, Vol. 57, No. 4, 29.04.2016, p. 171-177.

Research output: Contribution to journalArticle

Horie, Yoshinori ; Ebinuma, Hirotoshi ; Kikuchi, Hiromasa ; Shiba, Syunsuke ; Nakamoto, Nobuhiro ; Kanai, Takanori. / Current status of alcoholic hepatitis in Japan (2012). In: Acta Hepatologica Japonica. 2016 ; Vol. 57, No. 4. pp. 171-177.
@article{d746c1e05e6346ad90daf9d039c6d5ca,
title = "Current status of alcoholic hepatitis in Japan (2012)",
abstract = "Severe alcoholic hepatitis (SAH) has a high mortality rate. Ability of Japan Alcoholic Hepatitis Score (JAS) to predict outcome was confirmed by examining the data of 90 patients with AH in 2012: 53 had moderate AH of whom 45 were alive and 8 were dead, while 37 had SAH of whom 21 were alive and 16 were dead. The prevalence of DIC was higher in patients who had died, while TB at 5 days was higher in SAH patients who had died. WBC and PT (INR) at 5 days were higher in moderate AH patients who had died. These results suggest that JAS allows stratification of the risk of death and can help manage patients with AH. Irrespective of severity, the treatment such as steroid should be carried out if WBC, PT (INR) or TB at 5 days were not yet fully recovered.",
keywords = "Alcoholic hepatitis, Bilirubin prothrombin time, Corticosteroids, Japan Alcoholic Hepatitis Score",
author = "Yoshinori Horie and Hirotoshi Ebinuma and Hiromasa Kikuchi and Syunsuke Shiba and Nobuhiro Nakamoto and Takanori Kanai",
year = "2016",
month = "4",
day = "29",
doi = "10.2957/kanzo.57.171",
language = "English",
volume = "57",
pages = "171--177",
journal = "Acta Hepatologica Japonica",
issn = "0451-4203",
publisher = "Japan Society of Hepatology",
number = "4",

}

TY - JOUR

T1 - Current status of alcoholic hepatitis in Japan (2012)

AU - Horie, Yoshinori

AU - Ebinuma, Hirotoshi

AU - Kikuchi, Hiromasa

AU - Shiba, Syunsuke

AU - Nakamoto, Nobuhiro

AU - Kanai, Takanori

PY - 2016/4/29

Y1 - 2016/4/29

N2 - Severe alcoholic hepatitis (SAH) has a high mortality rate. Ability of Japan Alcoholic Hepatitis Score (JAS) to predict outcome was confirmed by examining the data of 90 patients with AH in 2012: 53 had moderate AH of whom 45 were alive and 8 were dead, while 37 had SAH of whom 21 were alive and 16 were dead. The prevalence of DIC was higher in patients who had died, while TB at 5 days was higher in SAH patients who had died. WBC and PT (INR) at 5 days were higher in moderate AH patients who had died. These results suggest that JAS allows stratification of the risk of death and can help manage patients with AH. Irrespective of severity, the treatment such as steroid should be carried out if WBC, PT (INR) or TB at 5 days were not yet fully recovered.

AB - Severe alcoholic hepatitis (SAH) has a high mortality rate. Ability of Japan Alcoholic Hepatitis Score (JAS) to predict outcome was confirmed by examining the data of 90 patients with AH in 2012: 53 had moderate AH of whom 45 were alive and 8 were dead, while 37 had SAH of whom 21 were alive and 16 were dead. The prevalence of DIC was higher in patients who had died, while TB at 5 days was higher in SAH patients who had died. WBC and PT (INR) at 5 days were higher in moderate AH patients who had died. These results suggest that JAS allows stratification of the risk of death and can help manage patients with AH. Irrespective of severity, the treatment such as steroid should be carried out if WBC, PT (INR) or TB at 5 days were not yet fully recovered.

KW - Alcoholic hepatitis

KW - Bilirubin prothrombin time

KW - Corticosteroids

KW - Japan Alcoholic Hepatitis Score

UR - http://www.scopus.com/inward/record.url?scp=84964808163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964808163&partnerID=8YFLogxK

U2 - 10.2957/kanzo.57.171

DO - 10.2957/kanzo.57.171

M3 - Article

AN - SCOPUS:84964808163

VL - 57

SP - 171

EP - 177

JO - Acta Hepatologica Japonica

JF - Acta Hepatologica Japonica

SN - 0451-4203

IS - 4

ER -