Current status of the organ replacement approach for malignancies and an overture for organ bioengineering and regenerative medicine

Taizo Hibi, Masahiro Shinoda, Osamu Itano, Yuko Kitagawa

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Significant achievements in the organ replacement approach for malignancies over the last 2 decades opened new horizons, and the age of Transplant Oncology has dawned. The indications of liver transplantation for malignancies have been carefully expanded by a strict patient selection to assure comparable outcomes with non-malignant diseases. Currently, the Milan criteria, gold standard for hepatocellular carcinoma, are being challenged by high-volume centers worldwide. Neoadjuvant chemoradiation therapy and liver transplantation for unresectable hilar cholangiocarcinoma has been successful in specialized institutions. For other primary and metastatic liver tumors, clinical evidence to establish standardized criteria is lacking. Intestinal and multivisceral transplantation is an option for low-grade neoplasms deemed unresectable by conventional surgery. However, the procedure itself is in the adolescent stage. Solid organ transplantation for malignancies inevitably suffers from triple distress, i.e., oncological, immunological, and technical. Organ bioengineering and regenerative medicine should serve as the triple threat therapy and revolutionize Transplant Oncology.

Original languageEnglish
Pages (from-to)241-249
Number of pages9
JournalOrganogenesis
Volume10
Issue number2
DOIs
Publication statusPublished - 2014 Apr 1

Keywords

  • Autotransplantation
  • Intestinal transplantation
  • Liver transplantation
  • Malignant neoplasm
  • Multivisceral transplantation
  • Transplant oncology

ASJC Scopus subject areas

  • Embryology
  • Biomedical Engineering
  • Developmental Biology
  • Transplantation

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