Current status of uterus transplantation in primates and issues for clinical application

Iori Kisu, Kouji Banno, Makoto Mihara, Nobuhiko Suganuma, Daisuke Aoki

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: To clarify the current status of uterus transplantation (UT) and the medical, ethical, and social problems surrounding UT. Design: Systematic review. Setting: Not applicable. Patient(s): Mainly nonhuman primates and humans. Intervention(s): Not applicable. Main Outcome Measure(s): A systematic search of Pubmed with the terms "uterus/uterine transplantation" was performed for English-language articles to review the current status of UT and issues associated with its clinical application, with a focus on nonhuman primate and human studies on UT. Result(s): The first UT procedure in humans was conducted for a patient with absolute uterine infertility in Saudi Arabia in 2000. The transplanted uterus was removed after 99 days owing to prolapse and necrosis. That attempt led to a greater focus on basic UT experiments in animal models, including nonhuman primates. The subsequent accumulation of basic data has led to performance of UT in humans by groups in Turkey and Sweden. However, there has yet to be a pregnancy or delivery after allo-UT in primates. Moreover, there are many medical, ethical, and social problems that require examination before clinical application. Conclusion(s): Clinical application of UT has just begun, but more basic data are needed and medical, ethical, and social problems require thorough discussion before clinical application.

Original languageEnglish
Pages (from-to)280-294
Number of pages15
JournalFertility and Sterility
Volume100
Issue number1
DOIs
Publication statusPublished - 2013 Jul

Fingerprint

Primates
Uterus
Transplantation
Social Problems
Saudi Arabia
Prolapse
Turkey
PubMed
Sweden
Infertility
Necrosis
Language
Animal Models
Outcome Assessment (Health Care)
Pregnancy

Keywords

  • Mayer-Rokitansky-Küster-Hauser syndrome
  • surrogacy
  • uterine factor infertility
  • Uterus transplantation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Current status of uterus transplantation in primates and issues for clinical application. / Kisu, Iori; Banno, Kouji; Mihara, Makoto; Suganuma, Nobuhiko; Aoki, Daisuke.

In: Fertility and Sterility, Vol. 100, No. 1, 07.2013, p. 280-294.

Research output: Contribution to journalArticle

Kisu, Iori ; Banno, Kouji ; Mihara, Makoto ; Suganuma, Nobuhiko ; Aoki, Daisuke. / Current status of uterus transplantation in primates and issues for clinical application. In: Fertility and Sterility. 2013 ; Vol. 100, No. 1. pp. 280-294.
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