Current topics in pheochromocytoma

K. Nakao, H. Itoh, K. Takaya

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Pheochromocytoma is the tumor that produces catecholamines and originates from chromaffin cells, which are differentiated from sympathoadrenal progenitor cells of neural crest under the influence of glucocorticoids. Genetic abnormalities of familial pheochromocytomas have elucidated oncogenic genetic bases of the tumor, including gene abnormalities of the RET proto-oncogene in multiple endocrine neoplasia type 2, VHL gene in von Hippel Lindau's disease or the NFI gene in neurofibromatosis. Co- localization of various substances with catecholamines in the tumor, including neuropeptide Y, opioid peptides or adrenomullin, which is the recently identified vasodepressor peptide elevating cAMP production, isrecognized. The significance of these substances in modulating clinical features of pheochromocytomas is not fully understood. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
Pages (from-to)124s-128s
JournalBiomedicine and Pharmacotherapy
Volume54
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2000 Jun
Externally publishedYes

Keywords

  • Adrenal glands
  • Adrenomullin
  • Catecholamine
  • Hypertension
  • MEN
  • Neuropeptide Y
  • Oploid peptides
  • Pheochromocytoma
  • RET
  • Sympathetic nervous system
  • VHL gene

ASJC Scopus subject areas

  • Pharmacology

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