Cutaneous pemphigus vulgaris with skin features similar to the classic mucocutaneous type: A case report and review of the literature

S. Shinkuma, W. Nishie, A. Shibaki, D. Sawamura, K. Ito, Y. Tsuji-Abe, K. Natsuga, P. T. Chan, M. Amagai, H. Shimizu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease that specifically involves oral mucosa. It was recently shown that a very small number of patients with PV show no mucous membrane involvement although they have circulating autoantibodies directed against both desmoglein (Dsg)1 and Dsg3 that are associated with histopathological suprabasal acantholysis. These cases are classed as cutaneous-type PV. We report here a case of cutaneous-type PV that occurred in a 50-year-old man. Clinical examination revealed numerous tense and spreading blisters and erosions over the patient's entire body, similar to the classic mucocutaneous-type PV. Interestingly, none of the previously reported patients with cutaneous PV had shown skin features like those of mucocutaneous PV, whereas the present case clearly demonstrated very typical clinical features similar to those in mucocutaneous PV.

Original languageEnglish
Pages (from-to)724-728
Number of pages5
JournalClinical and Experimental Dermatology
Volume33
Issue number6
DOIs
Publication statusPublished - 2008 Nov

ASJC Scopus subject areas

  • Dermatology

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