TY - JOUR
T1 - Cutaneous pemphigus vulgaris with skin features similar to the classic mucocutaneous type
T2 - A case report and review of the literature
AU - Shinkuma, S.
AU - Nishie, W.
AU - Shibaki, A.
AU - Sawamura, D.
AU - Ito, K.
AU - Tsuji-Abe, Y.
AU - Natsuga, K.
AU - Chan, P. T.
AU - Amagai, M.
AU - Shimizu, H.
PY - 2008/11
Y1 - 2008/11
N2 - Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease that specifically involves oral mucosa. It was recently shown that a very small number of patients with PV show no mucous membrane involvement although they have circulating autoantibodies directed against both desmoglein (Dsg)1 and Dsg3 that are associated with histopathological suprabasal acantholysis. These cases are classed as cutaneous-type PV. We report here a case of cutaneous-type PV that occurred in a 50-year-old man. Clinical examination revealed numerous tense and spreading blisters and erosions over the patient's entire body, similar to the classic mucocutaneous-type PV. Interestingly, none of the previously reported patients with cutaneous PV had shown skin features like those of mucocutaneous PV, whereas the present case clearly demonstrated very typical clinical features similar to those in mucocutaneous PV.
AB - Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease that specifically involves oral mucosa. It was recently shown that a very small number of patients with PV show no mucous membrane involvement although they have circulating autoantibodies directed against both desmoglein (Dsg)1 and Dsg3 that are associated with histopathological suprabasal acantholysis. These cases are classed as cutaneous-type PV. We report here a case of cutaneous-type PV that occurred in a 50-year-old man. Clinical examination revealed numerous tense and spreading blisters and erosions over the patient's entire body, similar to the classic mucocutaneous-type PV. Interestingly, none of the previously reported patients with cutaneous PV had shown skin features like those of mucocutaneous PV, whereas the present case clearly demonstrated very typical clinical features similar to those in mucocutaneous PV.
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U2 - 10.1111/j.1365-2230.2008.02871.x
DO - 10.1111/j.1365-2230.2008.02871.x
M3 - Article
C2 - 18627395
AN - SCOPUS:53349153525
SN - 0307-6938
VL - 33
SP - 724
EP - 728
JO - Clinical and Experimental Dermatology
JF - Clinical and Experimental Dermatology
IS - 6
ER -