Cutaneous plasmacytosis: Report of 6 cases with or without systemic involvement

Rie Honda, Lorenzo Cerroni, Akiko Tanikawa, Tamotsu Ebihara, Masayuki Amagai, Akira Ishiko

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Cutaneous plasmacytosis and systemic plasmacytosis are rare entities arising primarily in patients of Japanese descent. The origin and exact pathogenesis are poorly understood. Objective: We sought to determine clinicopathologic features of cutaneous and systemic plasmacytosis. Methods: We describe the clinicopathologic features of 6 patients with cutaneous plasmacytosis with or without systemic involvement (male:female = 3:1; mean age: 49.7 years; median age: 50.5 years; age range: 29-64 years). Results: Patients presented clinically with multiple, red-brown infiltrated plaques and flat tumors, mainly located on the trunk. Histology revealed in all cases the presence of clusters of mature plasma cells within the dermis. Lymphoid follicles with reactive germinal centers were seen in 3 cases. Five cases showed the expected polyclonal expression of immunoglobulin light chain by the plasma cells, but monoclonality was observed in 1 case, thus showing overlapping features with cutaneous marginal zone lymphoma. One patient revealed overlapping features with multicentric Castleman disease. Limitations: This was a retrospective study on a relatively small number of patients. Conclusions: Despite typical clinical presentation, some of our patients presented with histopathologic and immunohistochemical features that deviated from the conventional appearance. Our observation confirms and expands previous observations of this elusive entity, suggesting that the spectrum of clinicopathologic presentations may be wider than previously recognized.

Original languageEnglish
Pages (from-to)978-985
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume68
Issue number6
DOIs
Publication statusPublished - 2013 Jun

Fingerprint

Skin
Plasma Cells
Immunoglobulin Light Chains
Germinal Center
Dermis
Lymphoma
Histology
Retrospective Studies
Observation
Neoplasms

Keywords

  • cutaneous plasmacytosis
  • marginal zone lymphoma
  • mixed connective-tissue disease
  • multicentric Castleman disease
  • sarcoid reaction
  • systemic plasmacytosis

ASJC Scopus subject areas

  • Dermatology

Cite this

Cutaneous plasmacytosis : Report of 6 cases with or without systemic involvement. / Honda, Rie; Cerroni, Lorenzo; Tanikawa, Akiko; Ebihara, Tamotsu; Amagai, Masayuki; Ishiko, Akira.

In: Journal of the American Academy of Dermatology, Vol. 68, No. 6, 06.2013, p. 978-985.

Research output: Contribution to journalArticle

Honda, Rie ; Cerroni, Lorenzo ; Tanikawa, Akiko ; Ebihara, Tamotsu ; Amagai, Masayuki ; Ishiko, Akira. / Cutaneous plasmacytosis : Report of 6 cases with or without systemic involvement. In: Journal of the American Academy of Dermatology. 2013 ; Vol. 68, No. 6. pp. 978-985.
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