Cutoff value of 1 h, 50 g glucose challenge test for screening of gestational diabetes mellitus in a Japanese population

Kei Miyakoshi, Mamoru Tanaka, Kazunori Ueno, Katsuhiko Uehara, Hitoshi Ishimoto, Yasunori Yoshimura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A total of 2651 consecutive native Japanese women who underwent a glucose challenge test (GCT) were retrospectively investigated. GCT was performed between 24 and 27 weeks of gestation; each subject received a 50 g oral glucose load without regard to the fasting or fed state, followed by a determination of 1 h venous plasma glucose level. Women demonstrating GCT exceeding 130 mg/dl received a 75 g, 2 h oral glucose tolerance test to determine whether or not they had gestational diabetes mellitus (GDM). All women with GDM were treated with a strict diabetic protocol including insulin therapy. Forty-nine (1.8%) women were diagnosed to have GDM. The receiver-operator characteristic curve identified a GCT finding above 140 mg/dl as the cutoff value for detecting GDM, which showed a sensitivity and specificity of 96 and 76%, respectively. Our results suggest that the cutoff value of a 50 g GCT is 140 mg/dl to identify pregnancies with GDM in a Japanese population.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalDiabetes Research and Clinical Practice
Volume60
Issue number1
DOIs
Publication statusPublished - 2003 Apr 1

Keywords

  • A Japanese population
  • Cutoff value
  • Gestational diabetes mellitus
  • Glucose challenge test

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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