CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer

Tomohiko Nishi, Hiroya Takeuchi, Sachiko Matsuda, Masaharu Ogura, Hirofumi Kawakubo, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Yoshiro Saikawa, Tai Omori, Yuukou Kitagawa

Research output: Contribution to journalArticle

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Abstract

Background: Esophagectomy is one of the most invasive surgical treatments for digestive tract cancer, and the blood levels of inflammatory cytokines such as interleukin-1, interleukin-6, and interleukin-8 are increased for several hours after surgery or in patients experiencing postoperative complications. CXCR2, an interleukin-8 receptor, is reportedly expressed in several carcinomas, and interleukin-8 signaling promotes cancer cell proliferation. The impact of postoperative complications following esophagectomy on long-term survival is controversial. In this study, we demonstrate the significance of CXCR2 expression and validate the effects of CXCR2 expression and postoperative complications on long-term prognosis of esophageal squamous cell carcinoma using resected specimens. Methods: Eighty-two specimens were sectioned from archived, paraffin-embedded tumor tissues obtained from patients with esophageal squamous cell carcinoma who underwent esophagectomy and extended lymphadenectomy for complete resection of cancer in our institute between 1997 and 2002. Immunohistochemistry was performed using a polyclonal antibody to CXCR2, and the correlation of stainability with clinicopathological factors and long-term survival was examined. Results: CXCR2 was expressed in 33 of 82 (40.2%) specimens. In the CXCR2-positive group, the recurrence-free survival and overall survival rates of patients who developed postoperative complications were both significantly lower than those for patients who did not develop any complications. In contrast, in the CXCR2-negative group, there was no significant difference in long-term prognosis between patients with and without complications. CXCR2 positivity combined with postoperative complications was an independent risk factor for subsequent tumor recurrence, showing the highest hazard ratio. Conclusions: Our results suggest that the patients with CXCR2-positive esophageal cancer who develop postoperative complications have a poor prognosis and should be carefully followed. Trial registration: This study was approved by Keio University School of Medicine Ethics Committee with a trial registration number of 2011-241.

Original languageEnglish
Article number232
JournalWorld Journal of Surgical Oncology
Volume13
Issue number1
DOIs
Publication statusPublished - 2015 Aug 1

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Esophageal Neoplasms
Esophagectomy
Survival
Neoplasms
Interleukin-8
Interleukin-8 Receptors
Recurrence
Ethics Committees
Lymph Node Excision
Interleukin-1
Paraffin
Gastrointestinal Tract
Interleukin-6
Survival Rate
Immunohistochemistry
Cell Proliferation
Medicine
Cytokines
Carcinoma
Antibodies

Keywords

  • CXCR2 protein
  • Esophagectomy
  • Postoperative complication

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer. / Nishi, Tomohiko; Takeuchi, Hiroya; Matsuda, Sachiko; Ogura, Masaharu; Kawakubo, Hirofumi; Fukuda, Kazumasa; Nakamura, Rieko; Takahashi, Tsunehiro; Wada, Norihito; Saikawa, Yoshiro; Omori, Tai; Kitagawa, Yuukou.

In: World Journal of Surgical Oncology, Vol. 13, No. 1, 232, 01.08.2015.

Research output: Contribution to journalArticle

Nishi, Tomohiko ; Takeuchi, Hiroya ; Matsuda, Sachiko ; Ogura, Masaharu ; Kawakubo, Hirofumi ; Fukuda, Kazumasa ; Nakamura, Rieko ; Takahashi, Tsunehiro ; Wada, Norihito ; Saikawa, Yoshiro ; Omori, Tai ; Kitagawa, Yuukou. / CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer. In: World Journal of Surgical Oncology. 2015 ; Vol. 13, No. 1.
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AU - Nishi, Tomohiko

AU - Takeuchi, Hiroya

AU - Matsuda, Sachiko

AU - Ogura, Masaharu

AU - Kawakubo, Hirofumi

AU - Fukuda, Kazumasa

AU - Nakamura, Rieko

AU - Takahashi, Tsunehiro

AU - Wada, Norihito

AU - Saikawa, Yoshiro

AU - Omori, Tai

AU - Kitagawa, Yuukou

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AB - Background: Esophagectomy is one of the most invasive surgical treatments for digestive tract cancer, and the blood levels of inflammatory cytokines such as interleukin-1, interleukin-6, and interleukin-8 are increased for several hours after surgery or in patients experiencing postoperative complications. CXCR2, an interleukin-8 receptor, is reportedly expressed in several carcinomas, and interleukin-8 signaling promotes cancer cell proliferation. The impact of postoperative complications following esophagectomy on long-term survival is controversial. In this study, we demonstrate the significance of CXCR2 expression and validate the effects of CXCR2 expression and postoperative complications on long-term prognosis of esophageal squamous cell carcinoma using resected specimens. Methods: Eighty-two specimens were sectioned from archived, paraffin-embedded tumor tissues obtained from patients with esophageal squamous cell carcinoma who underwent esophagectomy and extended lymphadenectomy for complete resection of cancer in our institute between 1997 and 2002. Immunohistochemistry was performed using a polyclonal antibody to CXCR2, and the correlation of stainability with clinicopathological factors and long-term survival was examined. Results: CXCR2 was expressed in 33 of 82 (40.2%) specimens. In the CXCR2-positive group, the recurrence-free survival and overall survival rates of patients who developed postoperative complications were both significantly lower than those for patients who did not develop any complications. In contrast, in the CXCR2-negative group, there was no significant difference in long-term prognosis between patients with and without complications. CXCR2 positivity combined with postoperative complications was an independent risk factor for subsequent tumor recurrence, showing the highest hazard ratio. Conclusions: Our results suggest that the patients with CXCR2-positive esophageal cancer who develop postoperative complications have a poor prognosis and should be carefully followed. Trial registration: This study was approved by Keio University School of Medicine Ethics Committee with a trial registration number of 2011-241.

KW - CXCR2 protein

KW - Esophagectomy

KW - Postoperative complication

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