Cycloaromatization and DNA cleavage of novel enyne-allene systems

Kazunobu Toshima, Kazumi Ohta, Atsuo Ohtsuka, Shuichi Matsumura, Masaya Nakata

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The novel enyne-allene sulfones 5-8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1-4; the enyne-allene sulfones 6-8 having a leaving group at the allylic position were aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) via the allene-ene-cumulene intermediate 10 and showed DNA-cleaving activities under basic conditions without any additive.

Original languageEnglish
Pages (from-to)1406-1407
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number18
DOIs
Publication statusPublished - 1993

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DNA Cleavage
Sulfones
DNA
Oxidation
Acids
Enediynes
Sulfides
propadiene

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Cycloaromatization and DNA cleavage of novel enyne-allene systems. / Toshima, Kazunobu; Ohta, Kazumi; Ohtsuka, Atsuo; Matsumura, Shuichi; Nakata, Masaya.

In: Journal of the Chemical Society, Chemical Communications, No. 18, 1993, p. 1406-1407.

Research output: Contribution to journalArticle

Toshima, Kazunobu ; Ohta, Kazumi ; Ohtsuka, Atsuo ; Matsumura, Shuichi ; Nakata, Masaya. / Cycloaromatization and DNA cleavage of novel enyne-allene systems. In: Journal of the Chemical Society, Chemical Communications. 1993 ; No. 18. pp. 1406-1407.
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