Abstract
In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O- tigloylingol (9), (24R)-cycloartane-3β,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.
| Original language | English |
|---|---|
| Pages (from-to) | 1370-1377 |
| Number of pages | 8 |
| Journal | Planta Medica |
| Volume | 78 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- Euphorbia neriifolia
- Euphorbiaceae
- TRAIL
- cycloartane triterpene
- death receptor
- ingol diterpene
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Toume, K., Nakazawa, T., Hoque, T., Ohtsuki, T., Arai, M., Koyano, T., Kowithayakorn, T., & Ishibashi, M. (2012). Cycloartane triterpenes and ingol diterpenes isolated from euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity. Planta Medica, 78(12), 1370-1377. https://doi.org/10.1055/s-0032-1314975