Cycloartane triterpenes and ingol diterpenes isolated from euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity

Kazufumi Toume, Takafumi Nakazawa, Tahmina Hoque, Takashi Ohtsuki, Midoria Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O- tigloylingol (9), (24R)-cycloartane-3β,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.

Original languageEnglish
Pages (from-to)1370-1377
Number of pages8
JournalPlanta Medica
Volume78
Issue number12
DOIs
Publication statusPublished - 2012

Keywords

  • Euphorbia neriifolia
  • Euphorbiaceae
  • TRAIL
  • cycloartane triterpene
  • death receptor
  • ingol diterpene

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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