Cycloartane triterpenes and ingol diterpenes isolated from euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity

Kazufumi Toume; Takafumi Nakazawa; Tahmina Hoque; Takashi Ohtsuki; Midoria Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi

doi:10.1055/s-0032-1314975

Cycloartane triterpenes and ingol diterpenes isolated from euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity

Kazufumi Toume, Takafumi Nakazawa, Tahmina Hoque, Takashi Ohtsuki, Midoria Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O- tigloylingol (9), (24R)-cycloartane-3β,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.

Original language	English
Pages (from-to)	1370-1377
Number of pages	8
Journal	Planta Medica
Volume	78
Issue number	12
DOIs	https://doi.org/10.1055/s-0032-1314975
Publication status	Published - 2012
Externally published	Yes

Keywords

Euphorbia neriifolia
Euphorbiaceae
TRAIL
cycloartane triterpene
death receptor
ingol diterpene

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1055/s-0032-1314975

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Cycloartane triterpenes and ingol diterpenes isolated from euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity. / Toume, Kazufumi; Nakazawa, Takafumi; Hoque, Tahmina; Ohtsuki, Takashi; Arai, Midoria; Koyano, Takashi; Kowithayakorn, Thaworn; Ishibashi, Masami.

In: Planta Medica, Vol. 78, No. 12, 2012, p. 1370-1377.

Research output: Contribution to journal › Article › peer-review

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abstract = "In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O- tigloylingol (9), (24R)-cycloartane-3β,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.",

keywords = "Euphorbia neriifolia, Euphorbiaceae, TRAIL, cycloartane triterpene, death receptor, ingol diterpene",

author = "Kazufumi Toume and Takafumi Nakazawa and Tahmina Hoque and Takashi Ohtsuki and Midoria Arai and Takashi Koyano and Thaworn Kowithayakorn and Masami Ishibashi",

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AU - Toume, Kazufumi

AU - Nakazawa, Takafumi

AU - Hoque, Tahmina

AU - Ohtsuki, Takashi

AU - Arai, Midoria

AU - Koyano, Takashi

AU - Kowithayakorn, Thaworn

AU - Ishibashi, Masami

PY - 2012

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AB - In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O- tigloylingol (9), (24R)-cycloartane-3β,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.

KW - Euphorbia neriifolia

KW - Euphorbiaceae

KW - TRAIL

KW - cycloartane triterpene

KW - death receptor

KW - ingol diterpene

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ER -

Cycloartane triterpenes and ingol diterpenes isolated from euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity

Abstract

Keywords

ASJC Scopus subject areas

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