Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity

Kazufumi Toume, Takafumi Nakazawa, Takashi Ohtsuki, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In our screening program for natural products that increase DR5 (death-receptor 5) expression, nine new cycloartane triterpenes, combretanones A-G (1-7), combretic acid A (8), and combretic acid B (9), were isolated from a MeOH extract of Combretum quadrangulare leaves. The known oleanane triterpenes (10, 11) and six known flavonols (12-17) were also isolated. The structures of 1-9 were elucidated by spectroscopic studies. Compounds 7, 9, 12, 16, and 17 enhanced DR5 expression, and 16 showed TRAIL-resistance abrogating activity.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalJournal of Natural Products
Volume74
Issue number2
DOIs
Publication statusPublished - 2011 Feb 25
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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