Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity

Kazufumi Toume; Takafumi Nakazawa; Takashi Ohtsuki; Midori A. Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi

doi:10.1021/np100784t

Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity

Kazufumi Toume, Takafumi Nakazawa, Takashi Ohtsuki, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

In our screening program for natural products that increase DR5 (death-receptor 5) expression, nine new cycloartane triterpenes, combretanones A-G (1-7), combretic acid A (8), and combretic acid B (9), were isolated from a MeOH extract of Combretum quadrangulare leaves. The known oleanane triterpenes (10, 11) and six known flavonols (12-17) were also isolated. The structures of 1-9 were elucidated by spectroscopic studies. Compounds 7, 9, 12, 16, and 17 enhanced DR5 expression, and 16 showed TRAIL-resistance abrogating activity.

Original language	English
Pages (from-to)	249-255
Number of pages	7
Journal	Journal of Natural Products
Volume	74
Issue number	2
DOIs	https://doi.org/10.1021/np100784t
Publication status	Published - 2011 Feb 25
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "In our screening program for natural products that increase DR5 (death-receptor 5) expression, nine new cycloartane triterpenes, combretanones A-G (1-7), combretic acid A (8), and combretic acid B (9), were isolated from a MeOH extract of Combretum quadrangulare leaves. The known oleanane triterpenes (10, 11) and six known flavonols (12-17) were also isolated. The structures of 1-9 were elucidated by spectroscopic studies. Compounds 7, 9, 12, 16, and 17 enhanced DR5 expression, and 16 showed TRAIL-resistance abrogating activity.",

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AU - Toume, Kazufumi

AU - Nakazawa, Takafumi

AU - Ohtsuki, Takashi

AU - Arai, Midori A.

AU - Koyano, Takashi

AU - Kowithayakorn, Thaworn

AU - Ishibashi, Masami

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Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity

Abstract

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