Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus

Tsutomu Sasaki, Kazuo Kitagawa, Shiro Sugiura, Emi Omura-Matsuoka, Shigeru Tanaka, Yoshiki Yagita, Hideyuki Okano, Masayasu Matsumoto, Masatsugu Hori

Research output: Contribution to journalArticle

Abstract

Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. The enhancement of dentate gyrus neurogenesis following ischemia was attenuated by COX inhibitors and in COX-2 knockout mice. These results demonstrate that COX-2 may modulate the enhancement of neurogenesis following ischemia.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalInternational Congress Series
Volume1252
Issue numberC
DOIs
Publication statusPublished - 2003 Jun 1

Fingerprint

Neurogenesis
Cyclooxygenase 2
Hippocampus
Stem Cells
Ischemia
Dentate Gyrus
Neuronal Plasticity
Cyclooxygenase Inhibitors
Encephalitis
Knockout Mice
Isoenzymes
Glutamic Acid

Keywords

  • COX-2
  • Hippocampus
  • Musashi-1
  • Neurogenesis
  • Neuronal progenitor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus. / Sasaki, Tsutomu; Kitagawa, Kazuo; Sugiura, Shiro; Omura-Matsuoka, Emi; Tanaka, Shigeru; Yagita, Yoshiki; Okano, Hideyuki; Matsumoto, Masayasu; Hori, Masatsugu.

In: International Congress Series, Vol. 1252, No. C, 01.06.2003, p. 445-450.

Research output: Contribution to journalArticle

Sasaki, T, Kitagawa, K, Sugiura, S, Omura-Matsuoka, E, Tanaka, S, Yagita, Y, Okano, H, Matsumoto, M & Hori, M 2003, 'Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus', International Congress Series, vol. 1252, no. C, pp. 445-450. https://doi.org/10.1016/S0531-5131(03)00071-2
Sasaki, Tsutomu ; Kitagawa, Kazuo ; Sugiura, Shiro ; Omura-Matsuoka, Emi ; Tanaka, Shigeru ; Yagita, Yoshiki ; Okano, Hideyuki ; Matsumoto, Masayasu ; Hori, Masatsugu. / Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus. In: International Congress Series. 2003 ; Vol. 1252, No. C. pp. 445-450.
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