Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus

Tsutomu Sasaki, Kazuo Kitagawa, Shiro Sugiura, Emi Omura-Matsuoka, Shigeru Tanaka, Yoshiki Yagita, Hideyuki Okano, Masayasu Matsumoto, Masatsugu Hori

Research output: Contribution to journalArticle

Abstract

Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. The enhancement of dentate gyrus neurogenesis following ischemia was attenuated by COX inhibitors and in COX-2 knockout mice. These results demonstrate that COX-2 may modulate the enhancement of neurogenesis following ischemia.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalInternational Congress Series
Volume1252
Issue numberC
DOIs
Publication statusPublished - 2003 Jun 1

Keywords

  • COX-2
  • Hippocampus
  • Musashi-1
  • Neurogenesis
  • Neuronal progenitor

ASJC Scopus subject areas

  • Medicine(all)

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