Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata

Takuhito Ohse, Shigeru Ohba, Takashi Yamamoto, Takashi Koyano, Kazuo Umezawa

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

In the course of screening for Ras function inhibitors, rocaglaol (1) and the related compounds, the known pyrimidinone (2) and the novel aglaiastatin (3), were isolated from a CHCl3 extract of the leaves of Aglaia odorata. The structure of 3 was elucidated as a novel cyclopentabenzofuran on the basis of its NMR spectroscopic data and by X-ray crystallographic analysis. These compounds (1-3) were potent inhibitors of the growth of K-ras-NRK cells, with IC50 values of 1-10 ng/mL, and induced normal morphology in K-ras-NRK cells at 10-30 ng/mL. They also specifically inhibited protein synthesis. Aglaiastatin (3) was slightly more potent than 1 and 2 in inhibiting cell growth. Aglaiastatin (3) reduced the amount of Ras, possibly by inhibiting its de novo synthesis.

Original languageEnglish
Pages (from-to)650-652
Number of pages3
JournalJournal of Natural Products
Volume59
Issue number7
DOIs
Publication statusPublished - 1996 Jul 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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