Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain

Hiroshi Inoue; Shinichi Kohsaka; Kazunari Yoshida; Mitsuhiro Ohtani; Shigeo Toya; Yasuzo Tsukada

doi:10.1016/S0304-3940(85)80122-1

Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain

Hiroshi Inoue, Shinichi Kohsaka, Kazunari Yoshida, Mitsuhiro Ohtani, Shigeo Toya, Yasuzo Tsukada

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	Neuroscience Letters
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(85)80122-1
Publication status	Published - 1985 Jan 1

Keywords

Thy-1.2
cyclosporin A
immunohistochemistry
immunosuppressant
neural transplantation

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(85)80122-1

Cite this

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title = "Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain",

abstract = "The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.",

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AU - Inoue, Hiroshi

AU - Kohsaka, Shinichi

AU - Yoshida, Kazunari

AU - Ohtani, Mitsuhiro

AU - Toya, Shigeo

AU - Tsukada, Yasuzo

PY - 1985/1/1

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N2 - The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.

AB - The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.

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KW - cyclosporin A

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Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain

Abstract

Keywords

ASJC Scopus subject areas

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