Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain

H. Inoue, S. Kohsaka, Kazunari Yoshida, M. Ohtani, S. Toya, Y. Tsukada

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Abstract

The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalNeuroscience Letters
Volume54
Issue number1
Publication statusPublished - 1985

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Third Ventricle
Cerebral Cortex
Cyclosporine
Transplantation
Immunosuppressive Agents
Brain
Organ Transplantation
Hematoxylin
Monoclonal Antibodies
Staining and Labeling
Control Groups

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain. / Inoue, H.; Kohsaka, S.; Yoshida, Kazunari; Ohtani, M.; Toya, S.; Tsukada, Y.

In: Neuroscience Letters, Vol. 54, No. 1, 1985, p. 85-90.

Research output: Contribution to journalArticle

Inoue, H. ; Kohsaka, S. ; Yoshida, Kazunari ; Ohtani, M. ; Toya, S. ; Tsukada, Y. / Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain. In: Neuroscience Letters. 1985 ; Vol. 54, No. 1. pp. 85-90.
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