Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

Yujiro Hayashi, Hiroaki Gotoh, Tomohiro Tamura, Hirofumi Yamaguchi, Ryouhei Masui, Mitsuru Shoji

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.

Original languageEnglish
Pages (from-to)16028-16029
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number46
DOIs
Publication statusPublished - 2005 Nov 23
Externally publishedYes

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Cyclopentanes
Enantioselectivity
Skeleton
Cysteine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction. / Hayashi, Yujiro; Gotoh, Hiroaki; Tamura, Tomohiro; Yamaguchi, Hirofumi; Masui, Ryouhei; Shoji, Mitsuru.

In: Journal of the American Chemical Society, Vol. 127, No. 46, 23.11.2005, p. 16028-16029.

Research output: Contribution to journalArticle

Hayashi, Y, Gotoh, H, Tamura, T, Yamaguchi, H, Masui, R & Shoji, M 2005, 'Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction', Journal of the American Chemical Society, vol. 127, no. 46, pp. 16028-16029. https://doi.org/10.1021/ja055740s
Hayashi, Yujiro ; Gotoh, Hiroaki ; Tamura, Tomohiro ; Yamaguchi, Hirofumi ; Masui, Ryouhei ; Shoji, Mitsuru. / Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 46. pp. 16028-16029.
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