Cystic tumor of the liver without ovarian-like stroma or bile duct communication: Two case reports and a review of the literature

Norihiro Kishida, Masahiro Shinoda, Yohei Masugi, Osamu Itano, Yoko Nishimura, Akihisa Ueno, Minoru Kitago, Taizo Hibi, Yuta Abe, Hiroshi Yagi, Akihiro Tanimoto, Minoru Tanabe, Michiie Sakamaoto, Yuukou Kitagawa

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Abstract

We report two cases of cystic neoplasm of the liver with mucinous epithelium in which both ovarian-like stroma and bile duct communication were absent. The first case was a 41-year-old woman. She underwent right trisegmentectomy due to a multilocular cystic lesion, 15 cm in diameter, with papillary nodular components in the medial segment and right lobe. Histologically, arborizing papillae were seen in the papillary lesion. The constituent neoplastic cells had sufficient cytoarchitectural atypia to be classified as high-grade dysplasia. The second case was a 60-year-old woman. She underwent left lobectomy due to a unilocular cystic lesion, 17 cm in diameter, in the left lobe. Histologically, the cyst wall was lined by low columnar epithelia with slight cellular atypia. In both cases, neither ovarian-like stroma nor bile duct communications were found throughout the resected specimen. According to the most recent World Health Organization (WHO) classification in 2010, cystic tumors of the liver with mucinous epithelium are classified as mucinous cystic neoplasms when ovarian-like stromata are found, and as intraductal papillary neoplasm of bile duct when bile duct communication exists. Therefore, we diagnosed the cystic tumors as 'biliary cystadenoma' according to the past WHO classification scheme from 2000. We believe that the combined absence of both ovarian-like stroma and bile duct communication is possible in mucinous cystic tumors of the liver. Herein, we have described the clinicopathologic features of the two cases and reviewed past cases in the literature.

Original languageEnglish
Article number229
JournalWorld Journal of Surgical Oncology
Volume12
Issue number1
DOIs
Publication statusPublished - 2014 Jul 21

Fingerprint

Bile Ducts
Communication
Epithelium
Liver
Neoplasms
Bile Duct Neoplasms
Cystadenoma
Liver Neoplasms
Ovarian Neoplasms
Cysts

Keywords

  • Bile duct communication
  • Cystic neoplasm
  • Intraductal papillary neoplasm of bile duct
  • Liver
  • Mucinous cystic neoplasm
  • Ovarian-like stroma

ASJC Scopus subject areas

  • Oncology
  • Surgery
  • Medicine(all)

Cite this

@article{536d867814fb4fa2ba44b6e2e5f5df15,
title = "Cystic tumor of the liver without ovarian-like stroma or bile duct communication: Two case reports and a review of the literature",
abstract = "We report two cases of cystic neoplasm of the liver with mucinous epithelium in which both ovarian-like stroma and bile duct communication were absent. The first case was a 41-year-old woman. She underwent right trisegmentectomy due to a multilocular cystic lesion, 15 cm in diameter, with papillary nodular components in the medial segment and right lobe. Histologically, arborizing papillae were seen in the papillary lesion. The constituent neoplastic cells had sufficient cytoarchitectural atypia to be classified as high-grade dysplasia. The second case was a 60-year-old woman. She underwent left lobectomy due to a unilocular cystic lesion, 17 cm in diameter, in the left lobe. Histologically, the cyst wall was lined by low columnar epithelia with slight cellular atypia. In both cases, neither ovarian-like stroma nor bile duct communications were found throughout the resected specimen. According to the most recent World Health Organization (WHO) classification in 2010, cystic tumors of the liver with mucinous epithelium are classified as mucinous cystic neoplasms when ovarian-like stromata are found, and as intraductal papillary neoplasm of bile duct when bile duct communication exists. Therefore, we diagnosed the cystic tumors as 'biliary cystadenoma' according to the past WHO classification scheme from 2000. We believe that the combined absence of both ovarian-like stroma and bile duct communication is possible in mucinous cystic tumors of the liver. Herein, we have described the clinicopathologic features of the two cases and reviewed past cases in the literature.",
keywords = "Bile duct communication, Cystic neoplasm, Intraductal papillary neoplasm of bile duct, Liver, Mucinous cystic neoplasm, Ovarian-like stroma",
author = "Norihiro Kishida and Masahiro Shinoda and Yohei Masugi and Osamu Itano and Yoko Nishimura and Akihisa Ueno and Minoru Kitago and Taizo Hibi and Yuta Abe and Hiroshi Yagi and Akihiro Tanimoto and Minoru Tanabe and Michiie Sakamaoto and Yuukou Kitagawa",
year = "2014",
month = "7",
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language = "English",
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T1 - Cystic tumor of the liver without ovarian-like stroma or bile duct communication

T2 - Two case reports and a review of the literature

AU - Kishida, Norihiro

AU - Shinoda, Masahiro

AU - Masugi, Yohei

AU - Itano, Osamu

AU - Nishimura, Yoko

AU - Ueno, Akihisa

AU - Kitago, Minoru

AU - Hibi, Taizo

AU - Abe, Yuta

AU - Yagi, Hiroshi

AU - Tanimoto, Akihiro

AU - Tanabe, Minoru

AU - Sakamaoto, Michiie

AU - Kitagawa, Yuukou

PY - 2014/7/21

Y1 - 2014/7/21

N2 - We report two cases of cystic neoplasm of the liver with mucinous epithelium in which both ovarian-like stroma and bile duct communication were absent. The first case was a 41-year-old woman. She underwent right trisegmentectomy due to a multilocular cystic lesion, 15 cm in diameter, with papillary nodular components in the medial segment and right lobe. Histologically, arborizing papillae were seen in the papillary lesion. The constituent neoplastic cells had sufficient cytoarchitectural atypia to be classified as high-grade dysplasia. The second case was a 60-year-old woman. She underwent left lobectomy due to a unilocular cystic lesion, 17 cm in diameter, in the left lobe. Histologically, the cyst wall was lined by low columnar epithelia with slight cellular atypia. In both cases, neither ovarian-like stroma nor bile duct communications were found throughout the resected specimen. According to the most recent World Health Organization (WHO) classification in 2010, cystic tumors of the liver with mucinous epithelium are classified as mucinous cystic neoplasms when ovarian-like stromata are found, and as intraductal papillary neoplasm of bile duct when bile duct communication exists. Therefore, we diagnosed the cystic tumors as 'biliary cystadenoma' according to the past WHO classification scheme from 2000. We believe that the combined absence of both ovarian-like stroma and bile duct communication is possible in mucinous cystic tumors of the liver. Herein, we have described the clinicopathologic features of the two cases and reviewed past cases in the literature.

AB - We report two cases of cystic neoplasm of the liver with mucinous epithelium in which both ovarian-like stroma and bile duct communication were absent. The first case was a 41-year-old woman. She underwent right trisegmentectomy due to a multilocular cystic lesion, 15 cm in diameter, with papillary nodular components in the medial segment and right lobe. Histologically, arborizing papillae were seen in the papillary lesion. The constituent neoplastic cells had sufficient cytoarchitectural atypia to be classified as high-grade dysplasia. The second case was a 60-year-old woman. She underwent left lobectomy due to a unilocular cystic lesion, 17 cm in diameter, in the left lobe. Histologically, the cyst wall was lined by low columnar epithelia with slight cellular atypia. In both cases, neither ovarian-like stroma nor bile duct communications were found throughout the resected specimen. According to the most recent World Health Organization (WHO) classification in 2010, cystic tumors of the liver with mucinous epithelium are classified as mucinous cystic neoplasms when ovarian-like stromata are found, and as intraductal papillary neoplasm of bile duct when bile duct communication exists. Therefore, we diagnosed the cystic tumors as 'biliary cystadenoma' according to the past WHO classification scheme from 2000. We believe that the combined absence of both ovarian-like stroma and bile duct communication is possible in mucinous cystic tumors of the liver. Herein, we have described the clinicopathologic features of the two cases and reviewed past cases in the literature.

KW - Bile duct communication

KW - Cystic neoplasm

KW - Intraductal papillary neoplasm of bile duct

KW - Liver

KW - Mucinous cystic neoplasm

KW - Ovarian-like stroma

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