Cytokine and chemokine profiles in neuromyelitis optica: Significance of interleukin-6

Akiyuki Uzawa, Masahiro Mori, Kimihito Arai, Yasunori Sato, Sei Hayakawa, Saeko Masuda, Junko Taniguchi, Satoshi Kuwabara

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking. Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO. Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined. Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers. Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO.

Original languageEnglish
Pages (from-to)1443-1452
Number of pages10
JournalMultiple Sclerosis
Volume16
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1
Externally publishedYes

Fingerprint

Neuromyelitis Optica
Chemokines
Interleukin-6
Cytokines
Multiple Sclerosis
Cerebrospinal Fluid
Interleukin-9
Chemokine CCL4
Chemokine CXCL10
Aquaporin 4
Cerebrospinal Fluid Proteins
Th17 Cells
Interleukin-1 Receptors
Interleukin-13
Glial Fibrillary Acidic Protein
Fibroblast Growth Factor 2
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Nervous System Diseases
Serum

Keywords

  • chemokine
  • cytokine
  • glial fibrillary acidic protein
  • immunohistochemical staining
  • interleukin-6
  • multiple sclerosis
  • neuromyelitis optica

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Uzawa, A., Mori, M., Arai, K., Sato, Y., Hayakawa, S., Masuda, S., ... Kuwabara, S. (2010). Cytokine and chemokine profiles in neuromyelitis optica: Significance of interleukin-6. Multiple Sclerosis, 16(12), 1443-1452. https://doi.org/10.1177/1352458510379247

Cytokine and chemokine profiles in neuromyelitis optica : Significance of interleukin-6. / Uzawa, Akiyuki; Mori, Masahiro; Arai, Kimihito; Sato, Yasunori; Hayakawa, Sei; Masuda, Saeko; Taniguchi, Junko; Kuwabara, Satoshi.

In: Multiple Sclerosis, Vol. 16, No. 12, 01.12.2010, p. 1443-1452.

Research output: Contribution to journalArticle

Uzawa, A, Mori, M, Arai, K, Sato, Y, Hayakawa, S, Masuda, S, Taniguchi, J & Kuwabara, S 2010, 'Cytokine and chemokine profiles in neuromyelitis optica: Significance of interleukin-6', Multiple Sclerosis, vol. 16, no. 12, pp. 1443-1452. https://doi.org/10.1177/1352458510379247
Uzawa, Akiyuki ; Mori, Masahiro ; Arai, Kimihito ; Sato, Yasunori ; Hayakawa, Sei ; Masuda, Saeko ; Taniguchi, Junko ; Kuwabara, Satoshi. / Cytokine and chemokine profiles in neuromyelitis optica : Significance of interleukin-6. In: Multiple Sclerosis. 2010 ; Vol. 16, No. 12. pp. 1443-1452.
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AB - Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking. Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO. Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined. Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers. Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO.

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