Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease

T. Fujii, T. Nojima, Hidekata Yasuoka, S. Satoh, K. Nakamura, M. Kuwana, A. Suwa, Michito Hirakata, T. Mimori

Research output: Contribution to journalArticle

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Abstract

Objectives. To determine cytokines and MHC class II alleles in Japanese patients with adult Still's disease (ASD) and clarify the association between those profiles and chronic articular disease. Methods. Of 35 patients with ASD (13 men, 22 women, mean age at onset 34.0 yr), 17 (49%) had chronic arthritis (>6 months, chronic articular ASD) and 18 (51%) lacked chronic arthritis (systemic ASD). Cytokines and cytokine receptors in sera were measured by ELISA. Correlations of each cytokine with disease activity or C-reactive protein (CRP) were determined. MHC class II alleles were examined by polymerase chain reaction methods. Results. In chronic articular ASD, female gender was more frequent and liver dysfunction and myalgia were rarer than in systemic ASD. In active disease, the white blood cell count was lower, but total IgG was greater in patients with chronic articular ASD than in those with systemic ASD. Tumour necrosis factor (TNF) α, soluble TNF receptor 2 and interleukin (IL)-18 were increased in both types of ASD, even in remission. Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. Interferon γ and IL-8 remained increased only in chronic articular ASD, even when disease activity, including IL-6 and CRP, was low. DRB1*1501 (DR2) and DRB1*1201 (DR5) alleles were more frequent in chronic articular than in systemic ASD, whereas DQB1*0602 (DQ1) was frequently observed in both types of ASD. Conclusion. The present study suggests that ASD with chronic articular disease has distinct clinical, cytokine and immunogenetic profiles.

Original languageEnglish
Pages (from-to)1398-1404
Number of pages7
JournalRheumatology
Volume40
Issue number12
Publication statusPublished - 2001

Fingerprint

Immunogenetics
Chronic Disease
Joints
Cytokines
C-Reactive Protein
Interleukin-18
Alleles
Arthritis
Receptors, Tumor Necrosis Factor, Type II
Cytokine Receptors

Keywords

  • Adult Still's disease
  • Chronic arthritis
  • Cytokines
  • MHC class II alleles

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Fujii, T., Nojima, T., Yasuoka, H., Satoh, S., Nakamura, K., Kuwana, M., ... Mimori, T. (2001). Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease. Rheumatology, 40(12), 1398-1404.

Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease. / Fujii, T.; Nojima, T.; Yasuoka, Hidekata; Satoh, S.; Nakamura, K.; Kuwana, M.; Suwa, A.; Hirakata, Michito; Mimori, T.

In: Rheumatology, Vol. 40, No. 12, 2001, p. 1398-1404.

Research output: Contribution to journalArticle

Fujii, T, Nojima, T, Yasuoka, H, Satoh, S, Nakamura, K, Kuwana, M, Suwa, A, Hirakata, M & Mimori, T 2001, 'Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease', Rheumatology, vol. 40, no. 12, pp. 1398-1404.
Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M et al. Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease. Rheumatology. 2001;40(12):1398-1404.
Fujii, T. ; Nojima, T. ; Yasuoka, Hidekata ; Satoh, S. ; Nakamura, K. ; Kuwana, M. ; Suwa, A. ; Hirakata, Michito ; Mimori, T. / Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease. In: Rheumatology. 2001 ; Vol. 40, No. 12. pp. 1398-1404.
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abstract = "Objectives. To determine cytokines and MHC class II alleles in Japanese patients with adult Still's disease (ASD) and clarify the association between those profiles and chronic articular disease. Methods. Of 35 patients with ASD (13 men, 22 women, mean age at onset 34.0 yr), 17 (49{\%}) had chronic arthritis (>6 months, chronic articular ASD) and 18 (51{\%}) lacked chronic arthritis (systemic ASD). Cytokines and cytokine receptors in sera were measured by ELISA. Correlations of each cytokine with disease activity or C-reactive protein (CRP) were determined. MHC class II alleles were examined by polymerase chain reaction methods. Results. In chronic articular ASD, female gender was more frequent and liver dysfunction and myalgia were rarer than in systemic ASD. In active disease, the white blood cell count was lower, but total IgG was greater in patients with chronic articular ASD than in those with systemic ASD. Tumour necrosis factor (TNF) α, soluble TNF receptor 2 and interleukin (IL)-18 were increased in both types of ASD, even in remission. Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. Interferon γ and IL-8 remained increased only in chronic articular ASD, even when disease activity, including IL-6 and CRP, was low. DRB1*1501 (DR2) and DRB1*1201 (DR5) alleles were more frequent in chronic articular than in systemic ASD, whereas DQB1*0602 (DQ1) was frequently observed in both types of ASD. Conclusion. The present study suggests that ASD with chronic articular disease has distinct clinical, cytokine and immunogenetic profiles.",
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AU - Fujii, T.

AU - Nojima, T.

AU - Yasuoka, Hidekata

AU - Satoh, S.

AU - Nakamura, K.

AU - Kuwana, M.

AU - Suwa, A.

AU - Hirakata, Michito

AU - Mimori, T.

PY - 2001

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N2 - Objectives. To determine cytokines and MHC class II alleles in Japanese patients with adult Still's disease (ASD) and clarify the association between those profiles and chronic articular disease. Methods. Of 35 patients with ASD (13 men, 22 women, mean age at onset 34.0 yr), 17 (49%) had chronic arthritis (>6 months, chronic articular ASD) and 18 (51%) lacked chronic arthritis (systemic ASD). Cytokines and cytokine receptors in sera were measured by ELISA. Correlations of each cytokine with disease activity or C-reactive protein (CRP) were determined. MHC class II alleles were examined by polymerase chain reaction methods. Results. In chronic articular ASD, female gender was more frequent and liver dysfunction and myalgia were rarer than in systemic ASD. In active disease, the white blood cell count was lower, but total IgG was greater in patients with chronic articular ASD than in those with systemic ASD. Tumour necrosis factor (TNF) α, soluble TNF receptor 2 and interleukin (IL)-18 were increased in both types of ASD, even in remission. Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. Interferon γ and IL-8 remained increased only in chronic articular ASD, even when disease activity, including IL-6 and CRP, was low. DRB1*1501 (DR2) and DRB1*1201 (DR5) alleles were more frequent in chronic articular than in systemic ASD, whereas DQB1*0602 (DQ1) was frequently observed in both types of ASD. Conclusion. The present study suggests that ASD with chronic articular disease has distinct clinical, cytokine and immunogenetic profiles.

AB - Objectives. To determine cytokines and MHC class II alleles in Japanese patients with adult Still's disease (ASD) and clarify the association between those profiles and chronic articular disease. Methods. Of 35 patients with ASD (13 men, 22 women, mean age at onset 34.0 yr), 17 (49%) had chronic arthritis (>6 months, chronic articular ASD) and 18 (51%) lacked chronic arthritis (systemic ASD). Cytokines and cytokine receptors in sera were measured by ELISA. Correlations of each cytokine with disease activity or C-reactive protein (CRP) were determined. MHC class II alleles were examined by polymerase chain reaction methods. Results. In chronic articular ASD, female gender was more frequent and liver dysfunction and myalgia were rarer than in systemic ASD. In active disease, the white blood cell count was lower, but total IgG was greater in patients with chronic articular ASD than in those with systemic ASD. Tumour necrosis factor (TNF) α, soluble TNF receptor 2 and interleukin (IL)-18 were increased in both types of ASD, even in remission. Soluble IL-2 receptors, IL-4 and IL-18 levels were correlated with disease activity or CRP value only in chronic articular ASD. Interferon γ and IL-8 remained increased only in chronic articular ASD, even when disease activity, including IL-6 and CRP, was low. DRB1*1501 (DR2) and DRB1*1201 (DR5) alleles were more frequent in chronic articular than in systemic ASD, whereas DQB1*0602 (DQ1) was frequently observed in both types of ASD. Conclusion. The present study suggests that ASD with chronic articular disease has distinct clinical, cytokine and immunogenetic profiles.

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