Cytokine biomarker candidates in breast milk associated with the development of atopic dermatitis in 6-month-old infants

Shingo Ochiai, Naoki Shimojo, Yoshinori Morita, Minako Tomiita, Takayasu Arima, Yuzaburo Inoue, Mayuko Nakaya, Naoki Uehara, Yasunori Sato, Chisato Mori, Yoichi Suzuki, Yoichi Kohno

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: A few studies have reported that the quantity of selected cytokines/chemokines in breast milk might be associated with atopic dermatitis (AD). Using the multiplex cytokine assay system, we examined cytokines/chemokines in human milk in order to identify new biomarkers related to AD. Methods: We recruited 49 infants with or without AD who participated in a birth cohort and measured the concentrations of cytokines/chemokines in the colostrum (collected within 4-5 days after birth) and mature milk (collected at 1 month postpartum) received by the infants. Results: There were significant differences in the concentrations of interleukin (IL)-1β and IL-12p40 in the colostrum, and in those of IL-4, eotaxin, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α2 and MIP-1α in the mature milk between the milk received by infants who developed AD at the age of 6 months and that received by the control infants. There was weak to moderate correlation between those 6 cytokines/chemokines in mature milk. Atopic history and IgE levels of mothers were not related to cytokine/chemokine concentrations in breast milk. Logistic regression analyses showed that high levels of eotaxin in the mature milk were a risk for the development of AD at 6 months of age. Conclusion: These results suggest that several cytokines/chemokines, especially eotaxin, are potential biomarkers for development of AD in early infancy.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalInternational Archives of Allergy and Immunology
Volume160
Issue number4
DOIs
Publication statusPublished - 2013 Mar 1
Externally publishedYes

Fingerprint

Human Milk
Chemokines
Biomarkers
Atopic Dermatitis
Cytokines
Milk
Colostrum
Granulocyte-Macrophage Colony-Stimulating Factor
Parturition
Interleukins
Granulocyte Colony-Stimulating Factor
Dermatitis, Atopic, 6
Interleukin-1
Interleukin-4
Postpartum Period
Interferons
Immunoglobulin E
Logistic Models
History
Regression Analysis

Keywords

  • Atopic dermatitis
  • Breast milk
  • Chemokine
  • Cytokine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cytokine biomarker candidates in breast milk associated with the development of atopic dermatitis in 6-month-old infants. / Ochiai, Shingo; Shimojo, Naoki; Morita, Yoshinori; Tomiita, Minako; Arima, Takayasu; Inoue, Yuzaburo; Nakaya, Mayuko; Uehara, Naoki; Sato, Yasunori; Mori, Chisato; Suzuki, Yoichi; Kohno, Yoichi.

In: International Archives of Allergy and Immunology, Vol. 160, No. 4, 01.03.2013, p. 401-408.

Research output: Contribution to journalArticle

Ochiai, S, Shimojo, N, Morita, Y, Tomiita, M, Arima, T, Inoue, Y, Nakaya, M, Uehara, N, Sato, Y, Mori, C, Suzuki, Y & Kohno, Y 2013, 'Cytokine biomarker candidates in breast milk associated with the development of atopic dermatitis in 6-month-old infants', International Archives of Allergy and Immunology, vol. 160, no. 4, pp. 401-408. https://doi.org/10.1159/000342995
Ochiai, Shingo ; Shimojo, Naoki ; Morita, Yoshinori ; Tomiita, Minako ; Arima, Takayasu ; Inoue, Yuzaburo ; Nakaya, Mayuko ; Uehara, Naoki ; Sato, Yasunori ; Mori, Chisato ; Suzuki, Yoichi ; Kohno, Yoichi. / Cytokine biomarker candidates in breast milk associated with the development of atopic dermatitis in 6-month-old infants. In: International Archives of Allergy and Immunology. 2013 ; Vol. 160, No. 4. pp. 401-408.
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AU - Shimojo, Naoki

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AU - Tomiita, Minako

AU - Arima, Takayasu

AU - Inoue, Yuzaburo

AU - Nakaya, Mayuko

AU - Uehara, Naoki

AU - Sato, Yasunori

AU - Mori, Chisato

AU - Suzuki, Yoichi

AU - Kohno, Yoichi

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AB - Background: A few studies have reported that the quantity of selected cytokines/chemokines in breast milk might be associated with atopic dermatitis (AD). Using the multiplex cytokine assay system, we examined cytokines/chemokines in human milk in order to identify new biomarkers related to AD. Methods: We recruited 49 infants with or without AD who participated in a birth cohort and measured the concentrations of cytokines/chemokines in the colostrum (collected within 4-5 days after birth) and mature milk (collected at 1 month postpartum) received by the infants. Results: There were significant differences in the concentrations of interleukin (IL)-1β and IL-12p40 in the colostrum, and in those of IL-4, eotaxin, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α2 and MIP-1α in the mature milk between the milk received by infants who developed AD at the age of 6 months and that received by the control infants. There was weak to moderate correlation between those 6 cytokines/chemokines in mature milk. Atopic history and IgE levels of mothers were not related to cytokine/chemokine concentrations in breast milk. Logistic regression analyses showed that high levels of eotaxin in the mature milk were a risk for the development of AD at 6 months of age. Conclusion: These results suggest that several cytokines/chemokines, especially eotaxin, are potential biomarkers for development of AD in early infancy.

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